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Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat
Wang, Y; Huang, C; Cao, Y; Han, JS
关键词ketamine monoarthritis pain
刊名LIFE SCIENCES
2000-06-08
67期:3页:261-267
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]D-ASPARTATE NMDA ; CLINICAL-EXPERIENCE ; RECEPTORS ; INFLAMMATION ; TRANSMISSION ; INVOLVEMENT ; ANALGESIA ; NEURONS ; UPDATE ; MODEL
英文摘要

The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund′s adjuvant-induced monoarthritic pain model in rats. The results show: (1) sc injection of ketamine at a dose of 2 mg.kg(-1) or 10 mg.kg(-1) produced significant analgesia (P<0.01) in arthritic rats starting from the 2nd week and 3rd week, respectively. (2) Repeated administration of ketamine produced a significant reduction of the circumference of the arthritic ankle (P<0.05 and P<0.01 with different doses). (3) The body weight of the rats was not affected by continuous administration of ketamine for 4 weeks. No abnormal locomotor behavior was observed (It was concerned but not systemically evaluated in this study). The results suggest that repeated sc injection of ketamine for 4 weeks significantly reduce inflammatory pain in monoarthritis without notable aversive side effects. (C) 2000 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000087709700006
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59296
专题基础医学院_神经生物学系
作者单位Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Y,Huang, C,Cao, Y,et al. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat[J]. LIFE SCIENCES,2000,67(3):261-267.
APA Wang, Y,Huang, C,Cao, Y,&Han, JS.(2000).Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat.LIFE SCIENCES,67(3),261-267.
MLA Wang, Y,et al."Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat".LIFE SCIENCES 67.3(2000):261-267.
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