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The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model
Wu, Qi; Yang, Xiu-Wei
关键词Cibotium barometz Dicksoniaceae Rhizome Caco-2 cell monolayer model Human intestinal permeation
刊名JOURNAL OF ETHNOPHARMACOLOGY
2009-09-25
DOI10.1016/j.jep.2009.07.017
125期:3页:417-422
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]EFFLUX
英文摘要

Ethnopharmacological relevance: Cibotium barometz(L)J. Sm. (Dicksoniaceae) has been traditionally used as anti-inflammatory and anodyne.

Aim of the study: To investigate the constituents in the rhizomes of Cibotium barometz, and evaluate their permeability in the human Caco-2 model.

Materials and methods: The rhizomes extracts of Cibotium, barometz were isolated by chromatographic techniques. Structures of isolated compounds were identified by spectroscopic methods. The permeability of the main constituents was evaluated using human Caco-2 cell monolayer as a model system.

Results: Three unusual sesquiterpenes having 1-indanone nucleus (1, 3 and 4) and an unusual orthoester spiropyranosyl derivative of protocatechuic acid (2) were isolated from the rhizomes of Cibotium barometz. Among these, the bilateral permeation of 1, 3 and 4 in Caco-2 model was examined. The apparent permeability coefficients (P(app)) of 1 was identical with those of propranolol, which is often used as reference standard of high permeability. The P pp values of 3 and 4 were in agreement with those of atenolol, which is often used as reference standard of poor permeability. The permeation rates of 1, 3 and 4 increased linearly as a function of time up to 180 min and with the concentration within the test range of 25-200 mu M.

Conclusions: This is the first report on the presence of compounds 2 and 3 in this plant and 4 was a new compound. Compound 1 is assigned for a well-absorbed, and 2 and 3 are assigned for the poorly absorbed compounds in human intestine. A passive diffusion mechanism for transport of 1, 3 and 4 in Caco-2 model was proposed. The results provided some useful information for predicting the oral bioavailability of 1, 3 and 4. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000270763100008
项目编号2002AA2Z343C ; 2004AA2Z3783 ; 2006BA106A01-02
资助机构National High Technology Research and Development Program of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59297
专题北京大学药学院_天然药物学系
北京大学临床肿瘤学院_内镜中心
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Qi,Yang, Xiu-Wei. The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,125(3):417-422.
APA Wu, Qi,&Yang, Xiu-Wei.(2009).The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model.JOURNAL OF ETHNOPHARMACOLOGY,125(3),417-422.
MLA Wu, Qi,et al."The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model".JOURNAL OF ETHNOPHARMACOLOGY 125.3(2009):417-422.
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