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Studies on the synthesis and anti-osteoporosis of estrogen-GHRPs linkers
Wang, C; Cui, W; Zhao, M; Yang, J; Peng, SQ
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2003-01-06
13期:1页:143-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]HORMONE
英文摘要

The linkers of estrogen-GHRPs were prepared by the combination of estradiol, estrone, TyrGlyGlyPheLeuOH, and TyrGlyGlyPheLeuOH. Their anti-osteoporosis effect was evaluated by analyzing the data, for instance the weight of the body, femur, femur ash, the content of calcium and phosphor in the femur, the content of calcium and ALP activity in the serum, obtained from the corresponding bioassay in vivo. The results indicated that the anti-osteoporosis potency for estradiol, estrone, TyrGlyGlyPheLeuOH and TyrGlyGlyPheLeuNH(2) may be totally enhanced each other via the corresponding linkers. (C) 2002 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000180058000030
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59302
专题北京大学药学院
作者单位Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, C,Cui, W,Zhao, M,et al. Studies on the synthesis and anti-osteoporosis of estrogen-GHRPs linkers[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2003,13(1):143-146.
APA Wang, C,Cui, W,Zhao, M,Yang, J,&Peng, SQ.(2003).Studies on the synthesis and anti-osteoporosis of estrogen-GHRPs linkers.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,13(1),143-146.
MLA Wang, C,et al."Studies on the synthesis and anti-osteoporosis of estrogen-GHRPs linkers".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13.1(2003):143-146.
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