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学科主题: 临床医学
题名:
Corneal reinforcement using an acellular dermal matrix for an analysis of biocompatibility, mechanical properties, and transparency
作者: Liu, Ziyuan1; Ji, Jing1; Zhang, Jing1; Huang, Chen2; Meng, Zhaojun1; Qiu, Weiqiang1; Li, Xuemin1; Wang, Wei1
关键词: Biocompatibility ; Collagen ; Cornea ; Mechanical properties
刊名: ACTA BIOMATERIALIA
发表日期: 2012-09-01
DOI: 10.1016/j.actbio.2012.05.004
卷: 8, 期:9, 页:3326-3332
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: TISSUE ENGINEERING SCAFFOLD ; RECOMBINANT HUMAN COLLAGEN ; PORCINE CORNEA ; REPAIR ; SUBSTITUTES ; CLOSURE ; STROMA
英文摘要:

The aim of this study was to analyze the viability of using an acellular dermal matrix (ADM) as a reinforcement material for peripheral corneal thinning disease. The complete removal of cell components was confirmed by hematoxylin and eosin (H&E) and 4′,6-diamidino-2-phenylindole (DAPI) staining. Transmission electron microscopy determined that the stromal structure was well preserved. Uniaxial tests revealed that the ADM had strong mechanical properties. After being implanted into rabbit cornea the ADM showed no sign of rejection and even achieved good transparency 24 weeks post-surgery. H&E staining demonstrated that keratocytes grew in the ADM and the ADM-cornea interface became blurry. Picrosirius red staining revealed great changes of collagen in the ADM. Uniaxial testing of the reinforced cornea showed better mechanical strength than the normal rabbit cornea, but this did not exhibit statistical significance. These results suggest that ADM is a worthy candidate for future exploration as a reinforcement material for peripheral corneal thinning problems. (C) 2012 Acts Materialia Inc. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81170888 ; D101100050010035 ; 2011CB510205
项目资助者: National Natural Science Foundation of China ; Beijing Science and Technology Programs (Capital Clinical Application Research Project) ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000307625900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59303
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Key Lab Vis Loss & Restorat, Dept Ophthalmol,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Med Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Ziyuan,Ji, Jing,Zhang, Jing,et al. Corneal reinforcement using an acellular dermal matrix for an analysis of biocompatibility, mechanical properties, and transparency[J]. ACTA BIOMATERIALIA,2012,8(9):3326-3332.
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