IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
RAPID COMMUNICATION Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells
Han, Limin1,2; Zhao, Ganye1,2; Wang, Hui1,2; Tong, Tanjun1,2; Chen, Jun1,2
关键词calorie restriction sirtuin 1 ubiquitination
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2014-03-01
DOI10.1111/1440-1681.12199
41期:3页:165-168
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
资助者National Basic Research Programs of China ; National Natural Science Foundation of China ; National Basic Research Programs of China ; National Natural Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]LIFE-SPAN ; DEACETYLASE ; TRANSCRIPTION ; PROMOTES ; SURVIVAL ; STRESS ; P53 ; ACTIVATION ; COMPLEX ; NAD
英文摘要

Sirtuin (SIRT) 1 is a key protein in mediating the benefits of calorie restriction (CR) in mammals. However, the molecular mechanisms underlying CR-induced SIRT1 upregulation in mammals remain unclear. Herein we show that the elevated SIRT1 levels are not due to increased SIRT1 mRNA expression. but rather to enhanced SIRT1 protein stability as a result of reduced ubiquitin-proteasome degradation of SIRT1 under limited nutrient conditions. Our observations have important implications for improving healthy aging in humans.

语种英语
所属项目编号2012CB911203 ; 31100997
资助者National Basic Research Programs of China ; National Natural Science Foundation of China ; National Basic Research Programs of China ; National Natural Science Foundation of China
WOS记录号WOS:000332924300002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59308
专题北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Res Ctr Ageing, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Han, Limin,Zhao, Ganye,Wang, Hui,et al. RAPID COMMUNICATION Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2014,41(3):165-168.
APA Han, Limin,Zhao, Ganye,Wang, Hui,Tong, Tanjun,&Chen, Jun.(2014).RAPID COMMUNICATION Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,41(3),165-168.
MLA Han, Limin,et al."RAPID COMMUNICATION Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41.3(2014):165-168.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Han, Limin]的文章
[Zhao, Ganye]的文章
[Wang, Hui]的文章
百度学术
百度学术中相似的文章
[Han, Limin]的文章
[Zhao, Ganye]的文章
[Wang, Hui]的文章
必应学术
必应学术中相似的文章
[Han, Limin]的文章
[Zhao, Ganye]的文章
[Wang, Hui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。