|Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients|
|Ni, YB; Hu, DY; Yu, H; Li, CL; Liu, WL; Wang, HY; Li, L|
|关键词||unstable angina polymorphism fibrinogen platelet glycoprotein|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||CORONARY-ARTERY-DISEASE ; MYOCARDIAL-INFARCTION ; HEART-DISEASE ; IB-ALPHA ; PLASMA-FIBRINOGEN ; PIA POLYMORPHISM ; IIIA ; AMPLIFICATION ; POLYMERASE ; RISK|
Background: Inherited predisposition has been associated with coronary artery disease (CAD) in the white population.
Hypothesis: The objective of this study was to investigate the association between the risk of unstable angina (UA) and genetic factors believed to be associated with an increased tendency toward thrombosis (the variable number of tandem repeats, [VNTR] polymorphism of the platelet glycoprotein [GP] Ibalpha gene, pl(A1/A2) of the platelet GP IIIa gene, 448G/A of the Bbeta fibrinogen gene and Thr3l2Ala of the Aalpha fibrinogen gene) in Chinese patients with UA.
Methods: We performed a case/control study evaluating 69 Chinese patients (43 men, 26 women) with UA and 69 control subjects without CAD, individually matched forage and gender. The restriction fragment length polymorphism (RFLP) method was used to determine the genetic polymorphisms.
Results: The frequencies of GP Ibalpha C/B genotype and BP fibrinogen 448A allele were higher in patients with UA (46.4 vs. 30.4%, odds ratio [OR] 1.977, 95% confidence interval [CI] 0.98-3.97, p = 0.054, and 49.3 vs. 20.3%, OR 3.816, 95% CI 1.797-8.103, p = 0.000, respectively). Only four subjects (two cases, two controls) with GP IIIa pl(A2) allele were found, and there was no association between Act fibrinogen Thr312Ala polymorphism and UA.
Conclusions: Chinese patients with UA had increased frequencies of GP Ibalpha C/B genotype and BP fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA.
|作者单位||Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China|
|Ni, YB,Hu, DY,Yu, H,et al. Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients[J]. CLINICAL CARDIOLOGY,2004,27(8):455-458.|
|APA||Ni, YB.,Hu, DY.,Yu, H.,Li, CL.,Liu, WL.,...&Li, L.(2004).Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients.CLINICAL CARDIOLOGY,27(8),455-458.|
|MLA||Ni, YB,et al."Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients".CLINICAL CARDIOLOGY 27.8(2004):455-458.|