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Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients
Ni, YB; Hu, DY; Yu, H; Li, CL; Liu, WL; Wang, HY; Li, L
关键词unstable angina polymorphism fibrinogen platelet glycoprotein
刊名CLINICAL CARDIOLOGY
2004-08-01
27期:8页:455-458
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CORONARY-ARTERY-DISEASE ; MYOCARDIAL-INFARCTION ; HEART-DISEASE ; IB-ALPHA ; PLASMA-FIBRINOGEN ; PIA POLYMORPHISM ; IIIA ; AMPLIFICATION ; POLYMERASE ; RISK
英文摘要

Background: Inherited predisposition has been associated with coronary artery disease (CAD) in the white population.

Hypothesis: The objective of this study was to investigate the association between the risk of unstable angina (UA) and genetic factors believed to be associated with an increased tendency toward thrombosis (the variable number of tandem repeats, [VNTR] polymorphism of the platelet glycoprotein [GP] Ibalpha gene, pl(A1/A2) of the platelet GP IIIa gene, 448G/A of the Bbeta fibrinogen gene and Thr3l2Ala of the Aalpha fibrinogen gene) in Chinese patients with UA.

Methods: We performed a case/control study evaluating 69 Chinese patients (43 men, 26 women) with UA and 69 control subjects without CAD, individually matched forage and gender. The restriction fragment length polymorphism (RFLP) method was used to determine the genetic polymorphisms.

Results: The frequencies of GP Ibalpha C/B genotype and BP fibrinogen 448A allele were higher in patients with UA (46.4 vs. 30.4%, odds ratio [OR] 1.977, 95% confidence interval [CI] 0.98-3.97, p = 0.054, and 49.3 vs. 20.3%, OR 3.816, 95% CI 1.797-8.103, p = 0.000, respectively). Only four subjects (two cases, two controls) with GP IIIa pl(A2) allele were found, and there was no association between Act fibrinogen Thr312Ala polymorphism and UA.

Conclusions: Chinese patients with UA had increased frequencies of GP Ibalpha C/B genotype and BP fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA.

语种英语
WOS记录号WOS:000223044200007
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59312
专题北京大学第二临床医学院_心血管内科
作者单位Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
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GB/T 7714
Ni, YB,Hu, DY,Yu, H,et al. Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients[J]. CLINICAL CARDIOLOGY,2004,27(8):455-458.
APA Ni, YB.,Hu, DY.,Yu, H.,Li, CL.,Liu, WL.,...&Li, L.(2004).Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients.CLINICAL CARDIOLOGY,27(8),455-458.
MLA Ni, YB,et al."Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients".CLINICAL CARDIOLOGY 27.8(2004):455-458.
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