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学科主题临床医学
Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi
Zhou, Jing; Scherlag, Benjamin J.; Edwards, Jeffery; Jackman, Warren M.; Lazzara, Ralph; Po, Sunny S.
关键词atrial fibrillation ganglionated plexi fat pad autonomic nervous system window of vulnerability
刊名JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
2007
DOI10.1111/j.1540-8167.2006.00679.x
18期:1页:83-90
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CARDIAC NERVOUS-SYSTEM ; PULMONARY VEINS ; PARASYMPATHETIC INNERVATION ; MICROSCOPIC ANATOMY ; CANINE SINOATRIAL ; INITIATION ; ABLATION ; HUMANS ; GROSS ; MODEL
英文摘要

Introduction. The mechanism(s) whereby atrial ectopy induces atrial fibrillation (AF) is still poorly understood.

Methods and Results. In 12 dogs, we determined the refractory period (RP) along the right atrium (RA) and right superior pulmonary vein (RSPV), and AF inducibility with and without concurrent stimulation of the anterior right ganglionated plexi (ARGP) at the base of the RSPV. Multielectrode catheters were attached to the RSPV and RA with the distal electrodes close to ARGP. The RP and window of vulnerability (WOV), i.e., the longest S-1-S-2 minus the shortest S-1-S-2 at which AF was induced, were measured before and during incremental levels of ARGP stimulation. Mapping of the onset of AF was performed using the EnSite (R) mapping system (St. Jude Medical, St. Paul, MN, USA) positioned in the RA.

A single premature depolarization (PD) from the RSPV that did not induce AF without ARGP stimulation could do so with ARGP stimulation. The onset of AF consistently arose at the myocardium subtending the ARGP. With GP stimulation, the average WOV at the RSPV-atrial junction was significantly wider than at the RA appendage (65 +/- 27 vs. 8 +/- 17 msec, P < 0.05) or further along the RSPV sleeve (48 +/- 39 vs. 10 +/- 20 msec, P < 0.05). Even without GP stimulation, high intensity (10-20 mA) premature stimuli delivered at the RA appendage induced AF, originating from atrial tissue subtending the ARGP, presumably due to axonal conduction that activated the ARGP.

Conclusion. GP stimulation, subthreshold for atrial excitation, converts isolated PDs into AF-inducing PDs, suggesting that autonomic tone may play a critical role in the initiation of paroxysmal AF.

语种英语
WOS记录号WOS:000242833000019
引用统计
被引频次:93[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59321
专题北京大学第一临床医学院_心血管内科
作者单位1.Univ Oklahoma, Hlth Sci Ctr, Cardiac Arrhythmia Res Inst, Oklahoma City, OK 73104 USA
2.St Jude Med, St Paul, MN USA
3.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Jing,Scherlag, Benjamin J.,Edwards, Jeffery,et al. Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,2007,18(1):83-90.
APA Zhou, Jing,Scherlag, Benjamin J.,Edwards, Jeffery,Jackman, Warren M.,Lazzara, Ralph,&Po, Sunny S..(2007).Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi.JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY,18(1),83-90.
MLA Zhou, Jing,et al."Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi".JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 18.1(2007):83-90.
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