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学科主题: 公共卫生
题名:
Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case-control Study and Meta-analysis in 55,195 Individuals
作者: Wang, Du1,2; Ma, Jun3; Zhang, Su1; Hinney, Anke4; Hebebrand, Johannes4; Wang, Yan1; Wang, Hai-Jun1
刊名: OBESITY
发表日期: 2010-03-01
DOI: 10.1038/oby.2009.268
卷: 18, 期:3, 页:573-579
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]: MELANOCORTIN-4 RECEPTOR GENE ; EARLY-ONSET OBESITY ; FUNCTIONAL-CHARACTERIZATION ; CHILDHOOD OBESITY ; MISSENSE MUTATION ; BODY-MASS ; IDENTIFICATION ; POPULATION ; CHILDREN ; VARIANTS
英文摘要:

Recently, large-scaled studies suggested a negative association of the infrequent allele of the melanocortin-4 receptor (MC4R) V103I polymorphism with obesity. We conducted a Chinese case-control study, meta-analysis in East Asians and in all populations, in order to further assess the association between the V103I polymorphism and reduced body weight and to explore whether the association varies among different ethnic groups. We conducted a case-control study to analyze this polymorphism in 2,012 children of two independent study groups from Beijing, China, no association was found between the V103I polymorphism and obesity or obesity-related phenotypes (P > 0.10). In the meta-analysis of 3,526 individuals from six East Asian studies, I103 carriers had a 31% lower risk for obesity (odds ratio (OR) = 0.69, 95% confidence interval (CI): 0.50-0.94, P = 0.02). Subsequently, we performed a large meta-analysis of the six East Asian studies and 31 studies of other ethnic groups, involving 55,195 individuals with 19,822 obese cases and 35,373 nonobese controls. In total, the individuals with I103 allele had a 21% lower risk for obesity (OR = 0.79, 95% CI: 0.71-0.88, P < 0.0001). In conclusion, this study confirmed and extended the previous findings, suggesting the MC4R V103I polymorphism is negatively associated with human obesity. It provides significant evidence for the association in East Asian populations. Further large-scaled studies in East Asian populations are needed to validate the association.

语种: 英语
所属项目编号: 30700668 ; 20070001811 ; 01GS0482 ; 01GS0820 ; FP6 LSHMCT-2003-503041 ; HE 1446/4-1
项目资助者: National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; German Federal Ministry of Education and Research ; European Union ; Deutsche Forschungsgemeinschaft
WOS记录号: WOS:000275024100021
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59326
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Epidemiol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Div Maternal & Child Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Inst Child & Adolescent Hlth, Beijing 100871, Peoples R China
4.Univ Duisburg Essen, Dept Child & Adolescent Psychiat, Essen, Germany

Recommended Citation:
Wang, Du,Ma, Jun,Zhang, Su,et al. Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case-control Study and Meta-analysis in 55,195 Individuals[J]. OBESITY,2010,18(3):573-579.
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