IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats
Zhang, BH; Tang, CS; Du, JB
关键词vascular calcification heme oxygenase carbon monoxide cyclic GMP
刊名LIFE SCIENCES
2003-01-17
72期:9页:1027-1037
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]SMOOTH-MUSCLE CELLS ; BILIRUBIN ; REGULATOR
英文摘要

The aim of the present study was to investigate the change in heme oxygenase (HO)-carbon monoxide (CO)cyclic guanosine monophosphate (cGMP) pathway in vascular calcification. Vascular calcification model was established in rats by using vitamin D-3 and nicotine. Vascular calcium content, alkaline phosphatase (ALP) activity, HO activity, HbCO formation and content of cGMP in vessels were measured. Immunochemistry (IH) for HO 1 expression and in situ hybridization (ISH) for HO 1 mRNA were observed. Compared to those of control rats, the aortic calcium content and vascular ALP activity in rats of the calcified group (VDN group) were obviously increased, but HO 1 activity, CO concentration and cGMP content in vessels of rats in VDN group were markedly decreased. Expressions of HO-1 protein and mRNA were significantly decreased compared to control rats. Vascular calcification might induce a down regulation in vascular HO-CO-cGMP pathway. (C) 2002 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000180518400005
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59330
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, BH,Tang, CS,Du, JB. Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats[J]. LIFE SCIENCES,2003,72(9):1027-1037.
APA Zhang, BH,Tang, CS,&Du, JB.(2003).Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats.LIFE SCIENCES,72(9),1027-1037.
MLA Zhang, BH,et al."Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats".LIFE SCIENCES 72.9(2003):1027-1037.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, BH]的文章
[Tang, CS]的文章
[Du, JB]的文章
百度学术
百度学术中相似的文章
[Zhang, BH]的文章
[Tang, CS]的文章
[Du, JB]的文章
必应学术
必应学术中相似的文章
[Zhang, BH]的文章
[Tang, CS]的文章
[Du, JB]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。