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学科主题: 临床医学
题名:
Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats
作者: Zhang, BH; Tang, CS; Du, JB
关键词: vascular calcification ; heme oxygenase ; carbon monoxide ; cyclic GMP
刊名: LIFE SCIENCES
发表日期: 2003-01-17
卷: 72, 期:9, 页:1027-1037
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: SMOOTH-MUSCLE CELLS ; BILIRUBIN ; REGULATOR
英文摘要:

The aim of the present study was to investigate the change in heme oxygenase (HO)-carbon monoxide (CO)cyclic guanosine monophosphate (cGMP) pathway in vascular calcification. Vascular calcification model was established in rats by using vitamin D-3 and nicotine. Vascular calcium content, alkaline phosphatase (ALP) activity, HO activity, HbCO formation and content of cGMP in vessels were measured. Immunochemistry (IH) for HO 1 expression and in situ hybridization (ISH) for HO 1 mRNA were observed. Compared to those of control rats, the aortic calcium content and vascular ALP activity in rats of the calcified group (VDN group) were obviously increased, but HO 1 activity, CO concentration and cGMP content in vessels of rats in VDN group were markedly decreased. Expressions of HO-1 protein and mRNA were significantly decreased compared to control rats. Vascular calcification might induce a down regulation in vascular HO-CO-cGMP pathway. (C) 2002 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000180518400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59330
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, BH,Tang, CS,Du, JB. Changes of heme oxygenase-carbon monoxide system in vascular calcification in rats[J]. LIFE SCIENCES,2003,72(9):1027-1037.
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