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学科主题: 临床医学
题名:
A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection
作者: Jin, OY; Duan, JL; Baeyens, WRG; Delanghe, JR
关键词: salbutamol ; ion chromatography ; pharmacokinetics
刊名: TALANTA
发表日期: 2005-01-15
DOI: 10.1016/j.talanta.2004.01.026
卷: 65, 期:1, 页:1-6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; MULTIRESIDUE ANALYSIS ; BETA-AGONISTS ; URINE ; GAS ; BETA(2)-AGONISTS ; EXTRACTION ; ALBUTEROL ; SAMPLES
英文摘要:

A simple method for the study of the pharmacokinetics of salbutamol using ion chromatography with direct conductivity detection without chemical suppression is presented in this paper. Baseline separation of salbutamol from plasma components was achieved by using diluted HNO3 (2 mmol l(-1)) as mobile phase with acetonitrile (6%, v/v) as modifier. Atenolol was utilized as internal standard. Under the optimal conditions, the linear regression coefficients of the calibration curves are 0.996 within the concentration range of 1000-3 ng ml(-1) salbutamol. The detection limit (signal-to-noise ratio = 3) was 1 ng ml(-1) salbutamol. The noncompartmental pharmacokinetic parameters for salbutamol following administration of 8 mg salbutamol to 18 subjects were tested. The results coincided most satisfactorily with the results obtained by using reversed-phase high performance liquid chromatography (HPLC) with fluorescence detection. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000225381600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59340
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.State Univ Ghent, Fac Pharmaceut Sci, B-9000 Ghent, Belgium
2.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
3.Peking Univ Third Hosp, Dept Pharm, Peking Univ, Beijing 100083, Peoples R China
4.State Univ Ghent Hosp, Dept Clin Chem Microbiol & Immunol, B-9000 Ghent, Belgium

Recommended Citation:
Jin, OY,Duan, JL,Baeyens, WRG,et al. A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection[J]. TALANTA,2005,65(1):1-6.
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