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A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection
Jin, OY; Duan, JL; Baeyens, WRG; Delanghe, JR
关键词salbutamol ion chromatography pharmacokinetics
刊名TALANTA
2005-01-15
DOI10.1016/j.talanta.2004.01.026
65期:1页:1-6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; MULTIRESIDUE ANALYSIS ; BETA-AGONISTS ; URINE ; GAS ; BETA(2)-AGONISTS ; EXTRACTION ; ALBUTEROL ; SAMPLES
英文摘要

A simple method for the study of the pharmacokinetics of salbutamol using ion chromatography with direct conductivity detection without chemical suppression is presented in this paper. Baseline separation of salbutamol from plasma components was achieved by using diluted HNO3 (2 mmol l(-1)) as mobile phase with acetonitrile (6%, v/v) as modifier. Atenolol was utilized as internal standard. Under the optimal conditions, the linear regression coefficients of the calibration curves are 0.996 within the concentration range of 1000-3 ng ml(-1) salbutamol. The detection limit (signal-to-noise ratio = 3) was 1 ng ml(-1) salbutamol. The noncompartmental pharmacokinetic parameters for salbutamol following administration of 8 mg salbutamol to 18 subjects were tested. The results coincided most satisfactorily with the results obtained by using reversed-phase high performance liquid chromatography (HPLC) with fluorescence detection. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000225381600001
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59340
专题北京大学第三临床医学院_药剂科
作者单位1.State Univ Ghent, Fac Pharmaceut Sci, B-9000 Ghent, Belgium
2.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
3.Peking Univ Third Hosp, Dept Pharm, Peking Univ, Beijing 100083, Peoples R China
4.State Univ Ghent Hosp, Dept Clin Chem Microbiol & Immunol, B-9000 Ghent, Belgium
推荐引用方式
GB/T 7714
Jin, OY,Duan, JL,Baeyens, WRG,et al. A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection[J]. TALANTA,2005,65(1):1-6.
APA Jin, OY,Duan, JL,Baeyens, WRG,&Delanghe, JR.(2005).A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection.TALANTA,65(1),1-6.
MLA Jin, OY,et al."A simple method for the study of salbutamol pharmacokinetics by ion chromatography with direct conductivity detection".TALANTA 65.1(2005):1-6.
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