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IR@PKUHSC  > 北京大学临床肿瘤学院  > 肝胆胰外科  > 期刊论文
学科主题: 临床医学
题名:
SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors
作者: Lv, Ang1; Li, Zhongwu2; Tian, Xiuyun1; Guan, Xiaoya1; Zhao, Min3; Dong, Bin3; Hao, Chunyi1
刊名: PLOS ONE
发表日期: 2013-05-17
DOI: 10.1371/journal.pone.0062951
卷: 8, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: C-KIT ; MUTATIONS ; RISK ; RECURRENCE ; P27(KIP1) ; STOMACH ; ASSOCIATION ; INHIBITOR ; MESYLATE ; NORWAY
英文摘要:

Background and Aims: Considering the indication of adjuvant therapy, the recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current risk stratification schemes may still have room for improvement. This study seeks to analyze prognostic factors for primary GISTs from 3 aspects, including clinicopathological parameters, immunohistochemical biomarkers, and gene mutational status, and attempts to find novel valuable factors predicting the malignancy potential of GISTs.

Methods: Retrospective data from 114 primary GIST patients after R0 resection were collected. Clinicopathological data was obtained from medical records and re-evaluated. Immunohistochemical analysis was performed using the Tissue Microarray method for Ki67, p16, p27, p53, SKP2, CD133, and actin. KIT gene exons 9, 11, 13, and 17 and PDGFR alpha gene exons 12 and 18 were tested for mutations using PCR.

Results: Univariate analysis revealed the following factors as poor prognostic indicators for relapse-free survival with a median follow-up of 50 months: male gender, gastrointestinal bleeding, mitotic index >5/50HPFs, tumor size >5 cm, non-gastric site, necrosis, epithelioid or mixed cell type, surrounding tissue invasion, Ki67>5%, p16>20%, p53 index >10, SKP2>10%, and KIT exon 11 deletion. Besides mitotic index, tumor size and site, SKP2 high expression (RR = 2.91, 95% CI: 1.41-5.99, P = 0.004) and KIT exon 11 deletion (RR = 2.73, 95% CI: 1.04-7.16, P = 0.041) were also independent risk factors in multivariate analysis, with gastrointestinal bleeding also showing a trend towards significance (RR = 1.88, 95% CI: 0.98-3.64, P = 0.059). In addition, gastrointestinal bleeding and SKP2 high expression showed a good ability to stratify high-risk patients further.

Conclusion: Our results show that gastrointestinal bleeding, SKP2 high expression, and KIT exon 11 deletions may be useful indicators of high recurrence risk for primary GIST patients.

语种: 英语
所属项目编号: 81272765 ; Z121107001012083 ; 2009-2095 ; 7122030 ; 2009-2-18 ; 2010 B033 ; 10-04
项目资助者: National Natural Science Funding ; Capital Characteristic Clinical Application Research ; Key Project of Capital Medical Development Fund ; Beijing Municipal Natural Science Foundation ; Beijing&prime ; s Outstanding Talents Subsidy Scheme (215 Program) ; Beijing Municipal Science and Technology Commission NOVA Program ; Funding of Beijing Cancer Hospital
WOS记录号: WOS:000319107900018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59342
Appears in Collections:北京大学临床肿瘤学院_肝胆胰外科_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Hepatopancreatobiliary Surg, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Pathol, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Carcinogenesis & Translat Res, Ctr Lab, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China

Recommended Citation:
Lv, Ang,Li, Zhongwu,Tian, Xiuyun,et al. SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors[J]. PLOS ONE,2013,8(5).
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