IR@PKUHSC  > 北京大学临床肿瘤学院  > 肝胆胰外科
学科主题临床医学
SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors
Lv, Ang1; Li, Zhongwu2; Tian, Xiuyun1; Guan, Xiaoya1; Zhao, Min3; Dong, Bin3; Hao, Chunyi1
刊名PLOS ONE
2013-05-17
DOI10.1371/journal.pone.0062951
8期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]C-KIT ; MUTATIONS ; RISK ; RECURRENCE ; P27(KIP1) ; STOMACH ; ASSOCIATION ; INHIBITOR ; MESYLATE ; NORWAY
英文摘要

Background and Aims: Considering the indication of adjuvant therapy, the recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current risk stratification schemes may still have room for improvement. This study seeks to analyze prognostic factors for primary GISTs from 3 aspects, including clinicopathological parameters, immunohistochemical biomarkers, and gene mutational status, and attempts to find novel valuable factors predicting the malignancy potential of GISTs.

Methods: Retrospective data from 114 primary GIST patients after R0 resection were collected. Clinicopathological data was obtained from medical records and re-evaluated. Immunohistochemical analysis was performed using the Tissue Microarray method for Ki67, p16, p27, p53, SKP2, CD133, and actin. KIT gene exons 9, 11, 13, and 17 and PDGFR alpha gene exons 12 and 18 were tested for mutations using PCR.

Results: Univariate analysis revealed the following factors as poor prognostic indicators for relapse-free survival with a median follow-up of 50 months: male gender, gastrointestinal bleeding, mitotic index >5/50HPFs, tumor size >5 cm, non-gastric site, necrosis, epithelioid or mixed cell type, surrounding tissue invasion, Ki67>5%, p16>20%, p53 index >10, SKP2>10%, and KIT exon 11 deletion. Besides mitotic index, tumor size and site, SKP2 high expression (RR = 2.91, 95% CI: 1.41-5.99, P = 0.004) and KIT exon 11 deletion (RR = 2.73, 95% CI: 1.04-7.16, P = 0.041) were also independent risk factors in multivariate analysis, with gastrointestinal bleeding also showing a trend towards significance (RR = 1.88, 95% CI: 0.98-3.64, P = 0.059). In addition, gastrointestinal bleeding and SKP2 high expression showed a good ability to stratify high-risk patients further.

Conclusion: Our results show that gastrointestinal bleeding, SKP2 high expression, and KIT exon 11 deletions may be useful indicators of high recurrence risk for primary GIST patients.

语种英语
WOS记录号WOS:000319107900018
项目编号81272765 ; Z121107001012083 ; 2009-2095 ; 7122030 ; 2009-2-18 ; 2010 B033 ; 10-04
资助机构National Natural Science Funding ; Capital Characteristic Clinical Application Research ; Key Project of Capital Medical Development Fund ; Beijing Municipal Natural Science Foundation ; Beijing&prime ; s Outstanding Talents Subsidy Scheme (215 Program) ; Beijing Municipal Science and Technology Commission NOVA Program ; Funding of Beijing Cancer Hospital
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59342
专题北京大学临床肿瘤学院_肝胆胰外科
北京大学临床肿瘤学院_肝胆胰外二科
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_中心实验室
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Hepatopancreatobiliary Surg, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Pathol, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Carcinogenesis & Translat Res, Ctr Lab, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Lv, Ang,Li, Zhongwu,Tian, Xiuyun,et al. SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors[J]. PLOS ONE,2013,8(5).
APA Lv, Ang.,Li, Zhongwu.,Tian, Xiuyun.,Guan, Xiaoya.,Zhao, Min.,...&Hao, Chunyi.(2013).SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors.PLOS ONE,8(5).
MLA Lv, Ang,et al."SKP2 High Expression, KIT Exon 11 Deletions, and Gastrointestinal Bleeding as Predictors of Poor Prognosis in Primary Gastrointestinal Stromal Tumors".PLOS ONE 8.5(2013).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lv, Ang]的文章
[Li, Zhongwu]的文章
[Tian, Xiuyun]的文章
百度学术
百度学术中相似的文章
[Lv, Ang]的文章
[Li, Zhongwu]的文章
[Tian, Xiuyun]的文章
必应学术
必应学术中相似的文章
[Lv, Ang]的文章
[Li, Zhongwu]的文章
[Tian, Xiuyun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。