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学科主题: 基础医学
题名:
Multiple organ infection and the pathogenesis of SARS
作者: Gu, J; Gong, EC; Zhang, B; Zheng, J; Gao, ZF; Zhong, YF; Zou, WZ; Zhan, J; Wang, SL; Xie, ZG; Zhuang, H; Wu, BQ; Zhong, HH; Shao, HQ; Fang, WG; Gao, DS; Pei, F; Li, XW; He, ZP; Xu, DZ; Shi, XY; Anderson, VM; Leong, ASY
刊名: JOURNAL OF EXPERIMENTAL MEDICINE
发表日期: 2005-08-01
DOI: 10.1084/jem.20050828
卷: 202, 期:3, 页:415-424
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Immunology ; Research & Experimental Medicine
关键词[WOS]: ACUTE RESPIRATORY SYNDROME ; SYNDROME-ASSOCIATED CORONAVIRUS ; HONG-KONG ; OUTBREAK ; TISSUE ; INVOLVEMENT ; LYMPHOCYTES ; PATHOLOGY
英文摘要:

After > 8,000 infections and > 700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.

语种: 英语
WOS记录号: WOS:000230902100011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59345
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Dept Microbiol, Beijing 100083, Peoples R China
3.Beijing Ditan Hosp, Beijing 100011, Peoples R China
4.SUNY Hlth Sci Ctr, Brooklyn, NY 11203 USA
5.Univ Newcastle, Hunter Area Pathol Serv, Newcastle, NSW 2310, Australia
6.Univ Newcastle, Discipline Anat Pathol, Newcastle, NSW 2310, Australia

Recommended Citation:
Gu, J,Gong, EC,Zhang, B,et al. Multiple organ infection and the pathogenesis of SARS[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2005,202(3):415-424.
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