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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy
作者: Wang, Jiansheng1; Zhang, Jia1; Sun, Junping2; Han, Jiangli3; Xi, Yutao2; Wu, Geru2; Duan, Kristina X.2; Zhang, Mingxin1; Zhou, Suna1; Liu, Qi2
刊名: MEDICAL HYPOTHESES
发表日期: 2011-05-01
DOI: 10.1016/j.mehy.2011.01.036
卷: 76, 期:5, 页:695-696
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: MURINE LUNG-CANCER ; CARDIAC INJURY ; BERAPROST SODIUM ; GROWTH ; DOXORUBICIN ; ISCHEMIA ; SYNTHASE ; RECEPTOR ; CYCLOOXYGENASE-2 ; CARDIOTOXICITY
英文摘要:

Prostacyclin (PGI(2)) and its analogues protect from cardiovascular disease through pleiotropic effects such as vasodilation, inhibition of platelet aggregation, leukocyte adhesion, and vascular smooth muscle cell (VSMC) proliferation. Additionally, prostacyclin synthase (PGIS) and PGI(2) also possess anti-cancer properties. As of late (2009-2010), numerous studies have identified the deleterious side-effects of chemotherapy on the cardiovascular system, which have been deemed as a serious clinical issue. Cardiomyocyte damage, induced by oxidative stress, is one of the clinical consequences caused by routine cancer chemotherapy. Previous studies indicate iloprost, a PGI(2) analogue, can protect against doxorubicin-induced (DOX) cardiomyocyte injury in vitro and in vivo without compromising tumor suppression. Therefore, we hypothesize PGI(2) can be used as a cardioprotective supplement to attenuate the damaging cardiac effects caused by the traditional cancer chemotherapy regimen. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000290084600023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59348
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Xi An Jiao Tong Univ, Dept Thorac Oncosurg, Affiliated Hosp 1, Sch Med, Xian 710061, Shaanxi, Peoples R China
2.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA
3.Peking Univ Third Hosp, Dept Cardiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Jiansheng,Zhang, Jia,Sun, Junping,et al. Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy[J]. MEDICAL HYPOTHESES,2011,76(5):695-696.
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