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学科主题临床医学
Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy
Wang, Jiansheng1; Zhang, Jia1; Sun, Junping2; Han, Jiangli3; Xi, Yutao2; Wu, Geru2; Duan, Kristina X.2; Zhang, Mingxin1; Zhou, Suna1; Liu, Qi2
刊名MEDICAL HYPOTHESES
2011-05-01
DOI10.1016/j.mehy.2011.01.036
76期:5页:695-696
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]MURINE LUNG-CANCER ; CARDIAC INJURY ; BERAPROST SODIUM ; GROWTH ; DOXORUBICIN ; ISCHEMIA ; SYNTHASE ; RECEPTOR ; CYCLOOXYGENASE-2 ; CARDIOTOXICITY
英文摘要

Prostacyclin (PGI(2)) and its analogues protect from cardiovascular disease through pleiotropic effects such as vasodilation, inhibition of platelet aggregation, leukocyte adhesion, and vascular smooth muscle cell (VSMC) proliferation. Additionally, prostacyclin synthase (PGIS) and PGI(2) also possess anti-cancer properties. As of late (2009-2010), numerous studies have identified the deleterious side-effects of chemotherapy on the cardiovascular system, which have been deemed as a serious clinical issue. Cardiomyocyte damage, induced by oxidative stress, is one of the clinical consequences caused by routine cancer chemotherapy. Previous studies indicate iloprost, a PGI(2) analogue, can protect against doxorubicin-induced (DOX) cardiomyocyte injury in vitro and in vivo without compromising tumor suppression. Therefore, we hypothesize PGI(2) can be used as a cardioprotective supplement to attenuate the damaging cardiac effects caused by the traditional cancer chemotherapy regimen. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000290084600023
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59348
专题北京大学第三临床医学院_心血管内科
作者单位1.Xi An Jiao Tong Univ, Dept Thorac Oncosurg, Affiliated Hosp 1, Sch Med, Xian 710061, Shaanxi, Peoples R China
2.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA
3.Peking Univ Third Hosp, Dept Cardiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jiansheng,Zhang, Jia,Sun, Junping,et al. Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy[J]. MEDICAL HYPOTHESES,2011,76(5):695-696.
APA Wang, Jiansheng.,Zhang, Jia.,Sun, Junping.,Han, Jiangli.,Xi, Yutao.,...&Liu, Qi.(2011).Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy.MEDICAL HYPOTHESES,76(5),695-696.
MLA Wang, Jiansheng,et al."Prostacyclin administration as a beneficial supplement to the conventional cancer chemotherapy".MEDICAL HYPOTHESES 76.5(2011):695-696.
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