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学科主题: 临床医学
题名:
Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway
作者: Bai, Zhigang1; Zhang, Zhongtao1; Ye, Yingjiang2; Wang, Shan2
关键词: differentiation ; gastric cancer ; MUC2 ; PTEN ; PI3K ; sodium butyrate
刊名: CELL BIOLOGY INTERNATIONAL
发表日期: 2010-12-01
DOI: 10.1042/CBI20090481
卷: 34, 期:12, 页:1141-1145
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: PHOSPHATIDYLINOSITOL 3-KINASE ; HISTONE DEACETYLASE ; GENE-EXPRESSION ; PTEN ; INHIBITION ; PROTEINS
英文摘要:

NaB (sodium butyrate) inhibits cell proliferation and induces differentiation in a variety of tumour cells. In this study, we aimed to determine whether NaB induced differentiation and regulated the expression of the mucosal factor MUC2 through the PTEN/PI3K (phosphoinositide 3-kinase) pathway. BGC823 cells treated with NaB for 24-72 h showed marked inhibition of cell proliferation and alteration in cellular morphology. NaB treatment markedly increased the expression of PTEN and MUC2, but it decreased the expression of PI3K. These effects were enhanced by intervention with PI3K inhibitors and were reduced by intervention with PTEN siRNA. Hence, we conclude that NaB increased PTEN expression, promoted the expression of MUC2 and induced the differentiation of gastric cancer cells through the PTEN/PI3K signalling pathway.

语种: 英语
WOS记录号: WOS:000285903200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59350
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China

Recommended Citation:
Bai, Zhigang,Zhang, Zhongtao,Ye, Yingjiang,et al. Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway[J]. CELL BIOLOGY INTERNATIONAL,2010,34(12):1141-1145.
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