IR@PKUHSC  > 北京大学第二临床医学院  > 胃肠外科
学科主题临床医学
Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway
Bai, Zhigang1; Zhang, Zhongtao1; Ye, Yingjiang2; Wang, Shan2
关键词differentiation gastric cancer MUC2 PTEN PI3K sodium butyrate
刊名CELL BIOLOGY INTERNATIONAL
2010-12-01
DOI10.1042/CBI20090481
34期:12页:1141-1145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]PHOSPHATIDYLINOSITOL 3-KINASE ; HISTONE DEACETYLASE ; GENE-EXPRESSION ; PTEN ; INHIBITION ; PROTEINS
英文摘要

NaB (sodium butyrate) inhibits cell proliferation and induces differentiation in a variety of tumour cells. In this study, we aimed to determine whether NaB induced differentiation and regulated the expression of the mucosal factor MUC2 through the PTEN/PI3K (phosphoinositide 3-kinase) pathway. BGC823 cells treated with NaB for 24-72 h showed marked inhibition of cell proliferation and alteration in cellular morphology. NaB treatment markedly increased the expression of PTEN and MUC2, but it decreased the expression of PI3K. These effects were enhanced by intervention with PI3K inhibitors and were reduced by intervention with PTEN siRNA. Hence, we conclude that NaB increased PTEN expression, promoted the expression of MUC2 and induced the differentiation of gastric cancer cells through the PTEN/PI3K signalling pathway.

语种英语
WOS记录号WOS:000285903200002
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59350
专题北京大学第二临床医学院_胃肠外科
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
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GB/T 7714
Bai, Zhigang,Zhang, Zhongtao,Ye, Yingjiang,et al. Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway[J]. CELL BIOLOGY INTERNATIONAL,2010,34(12):1141-1145.
APA Bai, Zhigang,Zhang, Zhongtao,Ye, Yingjiang,&Wang, Shan.(2010).Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway.CELL BIOLOGY INTERNATIONAL,34(12),1141-1145.
MLA Bai, Zhigang,et al."Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway".CELL BIOLOGY INTERNATIONAL 34.12(2010):1141-1145.
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