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学科主题: 临床医学
题名:
Changes of plasma vWF level in response to the improvement of air quality: an observation of 114 healthy young adults
作者: Yuan, Zhonghai1; Chen, Yan1; Zhang, Ying1; Liu, Hui1; Liu, Qian1; Zhao, Jun1; Hu, Min2; Huang, Wei2; Wang, Guangfa; Zhu, Tong2; Zhang, Jim3; Zhu, Ping1
关键词: von Willebrand factor ; Air condition ; Gene polymorphism
刊名: ANNALS OF HEMATOLOGY
发表日期: 2013-04-01
DOI: 10.1007/s00277-013-1679-3
卷: 92, 期:4, 页:543-548
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: VON-WILLEBRAND-FACTOR ; ABO BLOOD-GROUP ; AMERICAN-HEART-ASSOCIATION ; CORONARY-ARTERY-DISEASE ; INCREASED SUSCEPTIBILITY ; CARDIOVASCULAR-DISEASE ; GENE POLYMORPHISM ; IN-VIVO ; POLLUTION ; INFLAMMATION
英文摘要:

Plasma von Willebrand factor (vWF) is an important factor involving in hemostasis and various cardiovascular diseases. Air pollution is related to many respiratory and cardiovascular diseases. During the Olympic Games Beijing 2008 period (August 8 to September 17, 2008) when air quality in Beijing improved greatly, we studied the relationship between plasma vWF level and the factors of air pollution index (API), ABO blood group, and polymorphisms in vWF gene in healthy young adults. We recruited 114 healthy medical students. In a period of more than 4 months around the period of Olympic Games Beijing 2008, six blood samples at stages 1 and 2 (before Olympic Games), stages 3 and 4 (during Olympic Games), and stages 5 and 6 (after Olympic Games) were taken from every participant for the measurement of plasma vWF level and genotyping of three SNPs (rs7954855, rs7965413, and rs216311) in vWF gene. Daily air pollution index near their living places was obtained from the officially published data. The average API began to decrease from stage 2, reached to nadir in stages 3 and 4, and increased but was still lower in stages 5 and 6. Plasma vWF decreased during the experimental period in all participants. The average plasma vWF decreased from stage 2 and remained lower in stages 3-6. vWF level varied greatly among the participants (from 30 to 170 %) but decreased proportionately when we analyzed their levels individually. Participants with O blood type had lower plasma vWF level than those with A, B, and AB blood types. Those with the SNP in vWF gene causing homozygous threonine at codon 1381 had lower plasma vWF level than those with homozygous alanine or heterozygous alanine/threonine. In the 114 normal individuals, the average plasma vWF level decreased during the period of Olympic Games Beijing 2008 when air quality improved greatly. This suggests that control of air pollution may be useful to prevent some diseases such as cardiovascular diseases.

语种: 英语
所属项目编号: 2008AA02503 ; 811D2211 ; 1R01ES015864 ; P30ES005022 ; 5P30ES007048
项目资助者: National 863 High-Tech Research and Development Program of China ; National Young Scientists Fund ; NIEHS
WOS记录号: WOS:000316015500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59352
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
2.Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
3.Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

Recommended Citation:
Yuan, Zhonghai,Chen, Yan,Zhang, Ying,et al. Changes of plasma vWF level in response to the improvement of air quality: an observation of 114 healthy young adults[J]. ANNALS OF HEMATOLOGY,2013,92(4):543-548.
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