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学科主题临床医学
The Assessment of Clinicopathological Features, Therapy Pattern and Survival Benefit of 162 Gastric Cancers with Liver Metastases
Li, Jian; Lu, Ming; Li, Jie; Zhang, Xiaodong; Li, Yan; Zhang, Xiaotian; Shen, Lin
关键词Gastric cancer with liver metastases Chemotherapy Extrahepatic metastases Local therapy Survival
刊名HEPATO-GASTROENTEROLOGY
2013-05-01
DOI10.5754/hge12729
60期:123页:628-632
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; HEPATIC RESECTION ; PHASE-III ; HEPATOCELLULAR-CARCINOMA ; SURGICAL-TREATMENT ; 1ST-LINE THERAPY ; CISPLATIN ; ADENOCARCINOMA ; FLUOROURACIL ; CHEMOTHERAPY
英文摘要

Background/Aims: This study investigated the influence of clinicopathological characteristics and different therapy patterns on overall survival of gastric cancer patients with liver metastases. Methodology: One hundred and sixty two patients were enrolled in this study. The data of clinicopathological characteristics, treatment methods and overall survival were collected. Univariate and multivariate analyses were performed using log-rank tests and Cox′s proportional hazard model, respectively. Results: Of all the patients enrolled, 27 (16.7%) had liver-only metastases and 48 patients (28.7%) received local treatment for liver metastases. The median overall survival of the 162 patients was 9.5 months (95%CI: 8.4-10.6). One- and two-year survival rates were 28.4% and 4.3%, respectively. There was no difference in the overall survival of patients who had received the different chemotherapy regimens. Multivariate analysis revealed that numbers of liver metastases 1-3, without extrahepatic metastases, receiving local treatment for liver metastases were better prognostic factors, and HR were 0.490, 0.479, 0.495. Conclusions: A smaller number of liver metastases, without extrahepatic metastases and local therapy for liver metastases are the independent survival factors for gastric cancer with liver metastases.

语种英语
WOS记录号WOS:000320740500047
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59353
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_消化肿瘤内科
作者单位Peking Univ, Canc Hosp & Inst, Dept GI Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Li, Jian,Lu, Ming,Li, Jie,et al. The Assessment of Clinicopathological Features, Therapy Pattern and Survival Benefit of 162 Gastric Cancers with Liver Metastases[J]. HEPATO-GASTROENTEROLOGY,2013,60(123):628-632.
APA Li, Jian.,Lu, Ming.,Li, Jie.,Zhang, Xiaodong.,Li, Yan.,...&Shen, Lin.(2013).The Assessment of Clinicopathological Features, Therapy Pattern and Survival Benefit of 162 Gastric Cancers with Liver Metastases.HEPATO-GASTROENTEROLOGY,60(123),628-632.
MLA Li, Jian,et al."The Assessment of Clinicopathological Features, Therapy Pattern and Survival Benefit of 162 Gastric Cancers with Liver Metastases".HEPATO-GASTROENTEROLOGY 60.123(2013):628-632.
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