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学科主题: 药物依赖
题名:
Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats
作者: Liang, JC; Zheng, JW
关键词: methamphetamine ; discrimination learning ; dizocilpine maleate ; N-methyl-D-aspartate receptors
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2000-07-01
卷: 21, 期:7, 页:605-608
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: VENTRAL TEGMENTAL AREA ; NUCLEUS-ACCUMBENS ; BEHAVIORAL SENSITIZATION ; GLUTAMATE ; ASPARTATE ; DOPAMINE ; STRESS ; DRUGS
英文摘要:

AIM: To study the effect of (+)-10, 11-dihydro-5-methyl-5H-dibenzo [ a, d] cyclohepten-5, 10-iminemaleate(dizocilpine maleate, MK-801) on the discriminative behavior of methamphetamine (MA). METHODS: Two lever and a fixed-ratio schedule of food presentation reinforcement program were used in discrimination test session. RESULTS: Rats can shape and maintain the discriminative behavior for MA (1 mg/kg, sc) and saline (1 mL/kg, sc). On pretreatment with dizocilpine maleate (0.1 mg/kg) in MA dependent rats, the correct discrimination percentage of MA was markedly decreased; but pretreatment with dizocilpine maleate (0.025, 0.05 mg/kg) did not block discrimination behavior of MA in antagonistic test. After injection of dizocilpine maleate (0.1 mg/kg) alone in MA dependent rats, six of the seven rats partially or completely responded on the MA associated lever whereas one did not. All of the rats had no substitution after injection of dizocilpine maleate (0.025, 0.05 mg/kg). CONCLUSION: N-methyl-D-aspartate (NMDA) receptor may be involved in psychological dependence of MA.

语种: 英语
WOS记录号: WOS:000088146100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59356
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Beijing Med Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Liang, JC,Zheng, JW. Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(7):605-608.
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