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Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats
Liang, JC; Zheng, JW
关键词methamphetamine discrimination learning dizocilpine maleate N-methyl-D-aspartate receptors
刊名ACTA PHARMACOLOGICA SINICA
2000-07-01
21期:7页:605-608
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]VENTRAL TEGMENTAL AREA ; NUCLEUS-ACCUMBENS ; BEHAVIORAL SENSITIZATION ; GLUTAMATE ; ASPARTATE ; DOPAMINE ; STRESS ; DRUGS
英文摘要

AIM: To study the effect of (+)-10, 11-dihydro-5-methyl-5H-dibenzo [ a, d] cyclohepten-5, 10-iminemaleate(dizocilpine maleate, MK-801) on the discriminative behavior of methamphetamine (MA). METHODS: Two lever and a fixed-ratio schedule of food presentation reinforcement program were used in discrimination test session. RESULTS: Rats can shape and maintain the discriminative behavior for MA (1 mg/kg, sc) and saline (1 mL/kg, sc). On pretreatment with dizocilpine maleate (0.1 mg/kg) in MA dependent rats, the correct discrimination percentage of MA was markedly decreased; but pretreatment with dizocilpine maleate (0.025, 0.05 mg/kg) did not block discrimination behavior of MA in antagonistic test. After injection of dizocilpine maleate (0.1 mg/kg) alone in MA dependent rats, six of the seven rats partially or completely responded on the MA associated lever whereas one did not. All of the rats had no substitution after injection of dizocilpine maleate (0.025, 0.05 mg/kg). CONCLUSION: N-methyl-D-aspartate (NMDA) receptor may be involved in psychological dependence of MA.

语种英语
WOS记录号WOS:000088146100006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59356
专题中国药物依赖性研究所
作者单位Beijing Med Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liang, JC,Zheng, JW. Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(7):605-608.
APA Liang, JC,&Zheng, JW.(2000).Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats.ACTA PHARMACOLOGICA SINICA,21(7),605-608.
MLA Liang, JC,et al."Effect of dizocilpine maleate on discriminative properties of methamphetamine in rats".ACTA PHARMACOLOGICA SINICA 21.7(2000):605-608.
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