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学科主题: 临床医学
题名:
Long-chain fatty acid oxidation changes in a beta 2 glycoprotein I-induced preeclampsia-like mouse model
作者: Ding, X.; Yang, Z.; Han, Y.; Yu, H.
关键词: Preeclampsia ; Antiphospholipid syndrome ; Fatty acid oxidation
刊名: PLACENTA
发表日期: 2014-06-01
DOI: 10.1016/j.placenta.2014.03.013
卷: 35, 期:6, 页:392-397
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Developmental Biology ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: PRIMARY ANTIPHOSPHOLIPID SYNDROME ; COENZYME-A DEHYDROGENASE ; EARLY GESTATIONAL STAGE ; ANTIBODIES ; WOMEN ; PREGNANCIES
英文摘要:

Introduction: Abnormal fatty acid oxidation (FAO) and lipid metabolism have been found related to preeclampsia (PE). Antiphospholipid syndrome (APS) as a clinical risk factor for PE has also been reported with abnormal lipid metabolism. However, the role of FAO in PE accompanied with APS is unknown. We aimed to investigate long-chain FAO changes in a PE-like rodent model induced by beta 2-glycoprotein I (beta 2GPI).

Methods: The PE-like model was established by injection of beta 2GPI (beta 2GPI group) or normal saline (control group) into C57BL/6J mice which were sacrificed on day 14 or 18 of gestation. Serum levels of anti-cardiolipin antibodies (aCL), anti-beta 2GPI antibodies (a beta 2GPI) and serum lipids were assayed. Lipid deposition in the placenta and maternal liver was detected by lipid staining. Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) mRNA and protein expression in the placenta and maternal liver was analyzed.

Results: The beta 2GPI group showed PE-like symptoms including hypertension, proteinuria and adverse pregnancy outcomes. Serum aCL, a beta 2GPI, free fatty acid (FFA) and triglyceride (TG) levels in the beta 2GPI group were significantly elevated compared with the corresponding control group (P < 0.05), while cholesterol showed no significant changes. Placenta and maternal liver fatty infiltration was found in the beta 2GPI group. LCHAD mRNA and protein expression in the placenta and maternal liver in the beta 2GPI group were significantly elevated compared with the corresponding control group (P < 0.05).

Conclusion: beta 2GPI can induce PE-like symptoms, elevated serum FFA and TG, and abnormal LCHAD expression in pregnant mice. Changes in long-chain FAO could be a factor linking PE and APS. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81370723 ; 7132215 ; 20130001110111
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Ministry of Education of China
WOS记录号: WOS:000337659400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59362
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Ding, X.,Yang, Z.,Han, Y.,et al. Long-chain fatty acid oxidation changes in a beta 2 glycoprotein I-induced preeclampsia-like mouse model[J]. PLACENTA,2014,35(6):392-397.
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