北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 泌尿外科  > 期刊论文
学科主题: 临床医学
题名:
Early and delayed castrations confer a similar survival advantage in TRAMP mice
作者: Zhang, Zai-Xian; Xu, Qing-Quan; Huang, Xiao-Bo; Zhu, Ji-Chuan; Wang, Xiao-Feng
关键词: castration ; prostate cancer ; survival ; TRAMP
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2009-04-01
DOI: 10.1038/aja.2009.20
卷: 11, 期:3, 页:291-297
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: AUTOCHTHONOUS PROSTATE-CANCER ; ANDROGEN RECEPTOR ; TRANSGENIC MOUSE ; PELVIC LYMPHADENECTOMY ; RADICAL PROSTATECTOMY ; RANDOMIZED-TRIAL ; LOCAL TREATMENT ; PHASE-III ; MODEL ; PROGRESSION
英文摘要:

The most appropriate time to introduce androgen deprivation therapy for prostate cancer remains controversial. Our aim was to evaluate the effects of early versus delayed surgical castration on prostate cancer progression and survival in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. TRAMP mice were randomly divided into three groups: the early castration group (on which castration was performed at the age of 4 weeks), the delayed castration group (on which castration was performed when abdominal tumours could be palpated), and the sham-castrated group. Mice were monitored daily throughout their lives until cancer-related death or the development of an obviously moribund appearance, at which time the individual mouse was killed. Androgen receptor expression in prostate tumours was also evaluated. The results shows that the average lifespan in early castration, delayed castration and sham-castrated groups were 54.1 weeks, 59.9 weeks and 39.1 weeks, respectively. Both early castration and delayed castration conferred a statistically significant survival advantage when compared with the sham-castrated group (P < 0.001). However, the difference in lifespan between the early castration group and the delayed castration group was not statistically significant (P = 0.85). The increase in lifespan in the TRAMP mice that received either early or delayed castration correlated with lower G/B value (genitourinary tract weight/body weight) at death than the sham-castrated mice. In conclusion, early and delayed castrations in TRAMP mice prolonged survival to a similar extent. This finding may provide a guide for clinical practice in prostate cancer therapy.

语种: 英语
所属项目编号: 30571854
项目资助者: National Natural Science Foundation of China ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
WOS记录号: WOS:000265889500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59365
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Zai-Xian,Xu, Qing-Quan,Huang, Xiao-Bo,et al. Early and delayed castrations confer a similar survival advantage in TRAMP mice[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(3):291-297.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Zai-Xian]'s Articles
[Xu, Qing-Quan]'s Articles
[Huang, Xiao-Bo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Zai-Xian]‘s Articles
[Xu, Qing-Quan]‘s Articles
[Huang, Xiao-Bo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace