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学科主题: 临床医学
题名:
Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer
作者: Lin, Qiang1,3; Gao, Xian-Shu1,2; Qiao, Xue-Ying1; Zhou, Zhi-Guo1; Zhang, Ping1; Chen, Kun3; Zhao, Yan-Nan3; Asaumi, Junichi4
关键词: esophageal neoplasm ; concurrent chemoradiotherapy ; cisplatin ; 5-fluorouracil ; dose escalation
刊名: ACTA MEDICA OKAYAMA
发表日期: 2008-02-01
卷: 62, 期:1, 页:37-44
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; COMBINED-MODALITY THERAPY ; RADIATION-THERAPY ; TOXICITY CRITERIA ; CHEMORADIOTHERAPY ; CHEMOTHERAPY ; RTOG
英文摘要:

We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m(2) on day 1, and 5-FU 500 mg/m(2) on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m(2) on day 1 and 5FU 700 mg/m(2) on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing.

语种: 英语
WOS记录号: WOS:000253549500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59371
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Hebei Med Univ Fourth Hosp, Dept Radiat Oncol 1, Shijiazhuang 050011, Peoples R China
2.Beijing Univ, Hosp 1, Dept Radiat Oncol, Beijing 10034, Peoples R China
3.N China Petr Bur Gen Hosp, Dept Oncol, Renqiu 062552, Peoples R China
4.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral & Maxillofacial Radiol, Okayama 7008558, Japan

Recommended Citation:
Lin, Qiang,Gao, Xian-Shu,Qiao, Xue-Ying,et al. Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer[J]. ACTA MEDICA OKAYAMA,2008,62(1):37-44.
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