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学科主题: 精神卫生
题名:
Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice
作者: Kohl, Christine1,2; Wang, Xiao-Dong2,3; Grosse, Jocelyn1; Fournier, Celine1; Harbich, Daniela2; Westerholz, Soeren2; Li, Ji-Tao4; Bacq, Alexandre1; Sippel, Claudia2; Hausch, Felix2; Sandi, Carmen1; Schmidt, Mathias V.2
关键词: Cell adhesion molecule ; Neuroligin-2 ; Early life stress ; Hippocampus ; Social behavior ; Aggression
刊名: PSYCHONEUROENDOCRINOLOGY
发表日期: 2015-05-01
DOI: 10.1016/j.psyneuen.2015.02.016
卷: 55, 页:128-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Neurosciences ; Psychiatry
研究领域[WOS]: Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: CELL-ADHESION MOLECULES ; INHIBITORY SYNAPSES ; SYNAPTIC FUNCTION ; SCHIZOPHRENIA ; NEUREXINS ; BEHAVIOR ; CHILDHOOD ; DISORDER ; VIOLENCE ; GENE
英文摘要:

Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associated with these diseases. Neuroligin-2 is a synaptic cell adhesion molecule, located at the postsynaptic membrane of inhibitory GABAergic synapses, and is involved in synaptic stabilization and maturation. Alterations in neuroligin-2 expression have previously been associated with changes in social behavior linked to psychiatric disorders, including schizophrenia and autism. In this study, we show that early-life stress, induced by limited nesting and bedding material, leads to impaired social recognition and increased aggression in adult mice, accompanied by increased expression levels of hippocampal neuroligin-2. Viral overexpression of hippocampal neuroligin-2 in adulthood mimics early-life stress-induced alterations in social behavior and social cognition. Moreover, viral knockdown of neuroligin-2 in the adult hippocampus attenuates the early-life stress-induced behavioral changes. Our results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition and its promising role as a novel therapeutic target for neuropsychiatric disorders. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: FP7-HEALTH-F2M-2007-201600 ; 31003AB-135710 ; 31003A-152614
项目资助者: European Union from the Swiss National Science Foundation ; Oak Foundation ; EPFL
WOS记录号: WOS:000353090100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59374
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Behav Genet, CH-1015 Lausanne, Switzerland
3.Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany
4.Zhejiang Univ, Sch Med, Zhejiang Prov Key Lab Neurobiol, Dept Neurobiol,Key Lab Med Neurobiol,Minist Hlth, Hangzhou 310058, Zhejiang, Peoples R China

Recommended Citation:
Kohl, Christine,Wang, Xiao-Dong,Grosse, Jocelyn,et al. Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice[J]. PSYCHONEUROENDOCRINOLOGY,2015,55:128-143.
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