IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice
Kohl, Christine1,2; Wang, Xiao-Dong2,3; Grosse, Jocelyn1; Fournier, Celine1; Harbich, Daniela2; Westerholz, Soeren2; Li, Ji-Tao4; Bacq, Alexandre1; Sippel, Claudia2; Hausch, Felix2; Sandi, Carmen1; Schmidt, Mathias V.2
关键词Cell adhesion molecule Neuroligin-2 Early life stress Hippocampus Social behavior Aggression
刊名PSYCHONEUROENDOCRINOLOGY
2015-05-01
DOI10.1016/j.psyneuen.2015.02.016
55页:128-143
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Neurosciences ; Psychiatry
资助者European Union from the Swiss National Science Foundation ; Oak Foundation ; EPFL ; European Union from the Swiss National Science Foundation ; Oak Foundation ; EPFL
研究领域[WOS]Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]CELL-ADHESION MOLECULES ; INHIBITORY SYNAPSES ; SYNAPTIC FUNCTION ; SCHIZOPHRENIA ; NEUREXINS ; BEHAVIOR ; CHILDHOOD ; DISORDER ; VIOLENCE ; GENE
英文摘要

Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associated with these diseases. Neuroligin-2 is a synaptic cell adhesion molecule, located at the postsynaptic membrane of inhibitory GABAergic synapses, and is involved in synaptic stabilization and maturation. Alterations in neuroligin-2 expression have previously been associated with changes in social behavior linked to psychiatric disorders, including schizophrenia and autism. In this study, we show that early-life stress, induced by limited nesting and bedding material, leads to impaired social recognition and increased aggression in adult mice, accompanied by increased expression levels of hippocampal neuroligin-2. Viral overexpression of hippocampal neuroligin-2 in adulthood mimics early-life stress-induced alterations in social behavior and social cognition. Moreover, viral knockdown of neuroligin-2 in the adult hippocampus attenuates the early-life stress-induced behavioral changes. Our results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition and its promising role as a novel therapeutic target for neuropsychiatric disorders. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号FP7-HEALTH-F2M-2007-201600 ; 31003AB-135710 ; 31003A-152614
资助者European Union from the Swiss National Science Foundation ; Oak Foundation ; EPFL ; European Union from the Swiss National Science Foundation ; Oak Foundation ; EPFL
WOS记录号WOS:000353090100012
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59374
Collection北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Behav Genet, CH-1015 Lausanne, Switzerland
3.Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany
4.Zhejiang Univ, Sch Med, Zhejiang Prov Key Lab Neurobiol, Dept Neurobiol,Key Lab Med Neurobiol,Minist Hlth, Hangzhou 310058, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Kohl, Christine,Wang, Xiao-Dong,Grosse, Jocelyn,et al. Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice[J]. PSYCHONEUROENDOCRINOLOGY,2015,55:128-143.
APA Kohl, Christine.,Wang, Xiao-Dong.,Grosse, Jocelyn.,Fournier, Celine.,Harbich, Daniela.,...&Schmidt, Mathias V..(2015).Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice.PSYCHONEUROENDOCRINOLOGY,55,128-143.
MLA Kohl, Christine,et al."Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice".PSYCHONEUROENDOCRINOLOGY 55(2015):128-143.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Kohl, Christine]'s Articles
[Wang, Xiao-Dong]'s Articles
[Grosse, Jocelyn]'s Articles
百度学术
百度学术Similar articles in
[Kohl, Christine]'s Articles
[Wang, Xiao-Dong]'s Articles
[Grosse, Jocelyn]'s Articles
必应学术
必应学术Similar articles in
[Kohl, Christine]'s Articles
[Wang, Xiao-Dong]'s Articles
[Grosse, Jocelyn]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.