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学科主题: 临床医学
题名:
Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects
作者: Zhang, L; Li, JT; Lu, Y; Li, MN; Zhang, YL; Liu, Y; Li, TY; Zhang, JW
关键词: levofloxacin ; high pressure liquid chromatography ; pharmacokinetics ; intravenous infusions
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2002-04-01
卷: 23, 期:4, 页:381-384
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: PHARMACODYNAMICS ; FLUOROQUINOLONE
英文摘要:

AIM: To study the pharmacokinetics of multiple doses intravenous infusion of levofloxacin instillation in Chinese! healthy volunteers. METHODS: Intravenous infusion of levofloxacin instillation 200 mg within 60 min was given to 10 male healthy volunteers for 7 d, on d 1 and d 7, once-daily, from 2 - 6 d twice-daily dosing. The concentrations of levofloxacin in serum and urine were assayed by HPLC. RESULTS: The main pharmacokinetic parameters after the first dosing were as follows: C-max was (2.4 +/- 0.4) mg/L; AUCO(0-infinity) was (16.1 +/- 1.4) mg(.)h(.)L(-1); T-1/(2beta) was (6.3 +/- 0. 3) h. The concentration in serum reached steady state within 72, h. The main parameters after the last dosing were as follows: C-ssmax was (2.9 +/- 0.4) mg/L; C-ssmin was (0.71 +/- 0.19) mg/L; C-av was (1.40 +/- 0.29) mg/L; AUC(ss0-12) was (17 +/- 3) mg(.)h(.)L(-1); T-1/(2beta) was (6.2 +/- 0.8) h. The 24-h cumulative urinary excretion rate was (88 +/- 5) %. From the calculation, the cumulative, rate was 1.20; the fluctuation index was 1.30. The difference of T-1/(2beta) and AUC between the first dosing and the last dosing was not significant, and the elimination rate of levofloxacin was not changed after multiple dosing. No clear adverse events were noted during this study. CONCLUSION: There was no accumulation of drug after the repeated intravenous infusion with 200 mg levofloxacin instillation for 7 d.

语种: 英语
WOS记录号: WOS:000174791500019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59387
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: Peking Univ, Inst Clin Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, L,Li, JT,Lu, Y,et al. Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects[J]. ACTA PHARMACOLOGICA SINICA,2002,23(4):381-384.
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