IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
学科主题临床医学
Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects
Zhang, L; Li, JT; Lu, Y; Li, MN; Zhang, YL; Liu, Y; Li, TY; Zhang, JW
关键词levofloxacin high pressure liquid chromatography pharmacokinetics intravenous infusions
刊名ACTA PHARMACOLOGICA SINICA
2002-04-01
23期:4页:381-384
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PHARMACODYNAMICS ; FLUOROQUINOLONE
英文摘要

AIM: To study the pharmacokinetics of multiple doses intravenous infusion of levofloxacin instillation in Chinese! healthy volunteers. METHODS: Intravenous infusion of levofloxacin instillation 200 mg within 60 min was given to 10 male healthy volunteers for 7 d, on d 1 and d 7, once-daily, from 2 - 6 d twice-daily dosing. The concentrations of levofloxacin in serum and urine were assayed by HPLC. RESULTS: The main pharmacokinetic parameters after the first dosing were as follows: C-max was (2.4 +/- 0.4) mg/L; AUCO(0-infinity) was (16.1 +/- 1.4) mg(.)h(.)L(-1); T-1/(2beta) was (6.3 +/- 0. 3) h. The concentration in serum reached steady state within 72, h. The main parameters after the last dosing were as follows: C-ssmax was (2.9 +/- 0.4) mg/L; C-ssmin was (0.71 +/- 0.19) mg/L; C-av was (1.40 +/- 0.29) mg/L; AUC(ss0-12) was (17 +/- 3) mg(.)h(.)L(-1); T-1/(2beta) was (6.2 +/- 0.8) h. The 24-h cumulative urinary excretion rate was (88 +/- 5) %. From the calculation, the cumulative, rate was 1.20; the fluctuation index was 1.30. The difference of T-1/(2beta) and AUC between the first dosing and the last dosing was not significant, and the elimination rate of levofloxacin was not changed after multiple dosing. No clear adverse events were noted during this study. CONCLUSION: There was no accumulation of drug after the repeated intravenous infusion with 200 mg levofloxacin instillation for 7 d.

语种英语
WOS记录号WOS:000174791500019
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59387
专题北京大学第一临床医学院_临床药理研究所
作者单位Peking Univ, Inst Clin Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, L,Li, JT,Lu, Y,et al. Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects[J]. ACTA PHARMACOLOGICA SINICA,2002,23(4):381-384.
APA Zhang, L.,Li, JT.,Lu, Y.,Li, MN.,Zhang, YL.,...&Zhang, JW.(2002).Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects.ACTA PHARMACOLOGICA SINICA,23(4),381-384.
MLA Zhang, L,et al."Pharmacokinetics of multiple intravenous instillation of levofloxacin in Chinese healthy subjects".ACTA PHARMACOLOGICA SINICA 23.4(2002):381-384.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, L]的文章
[Li, JT]的文章
[Lu, Y]的文章
百度学术
百度学术中相似的文章
[Zhang, L]的文章
[Li, JT]的文章
[Lu, Y]的文章
必应学术
必应学术中相似的文章
[Zhang, L]的文章
[Li, JT]的文章
[Lu, Y]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。