IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population
Cao, Bangwei1,2; Liu, Xing3,4; Hou, Fang1,2; Li, Wende5; Han, Zhonggang5; Zhang, Qipeng5; Dai, Yue6; Xu, Changqing7; Qi, Huimin1,2
关键词haplotype hepatitis virus B MxA gene promoter susceptibility
刊名LIVER INTERNATIONAL
2009-10-01
DOI10.1111/j.1478-3231.2009.02053.x
29期:9页:1383-1388
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者Beijing Municipal Natural Science Foundation ; Beijing Municipal Natural Science Foundation
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]NATURAL-HISTORY ; IN-VITRO ; INTERFERON ; POLYMORPHISMS ; REPLICATION ; SUSCEPTIBILITY ; INHIBITION ; EXPRESSION ; INDUCTION ; RESPONSES
英文摘要

Background/Aim: The Myxovirus resistance protein A gene (MxA) is a key component of the innate antiviral response and has previously been shown to inhibit several viruses. This study was designed to assess whether the haplotype in the MxA promoter region was associated with hepatitis B virus (HBV) infection in a Chinese population. Methods: Three hundred and twelve HBV-infected patients and 317 healthy volunteers were enrolled in this study. Two polymorphisms of -88 and -123 located in the MxA gene promoter were identified by the polymerase chain reaction-restriction fragment length polymorphism method. Results: The individual possessing haplotype GA, which was constructed by the two polymorphisms of -88G and -123A in the MxA gene promoter, was significantly associated with HBV infection [possessing one copy odds ratio (OR) = 1.69, 95% confidence interval (CI) 1.21-2.35; two copy OR = 2.84, 95% CI 1.12-7.21 respectively]. Conclusions: This case-control study suggested that the haplotype GA in the MxA gene promoter region would increase the susceptibility to HBV infection in a Chinese population.

语种英语
所属项目编号7092103
资助者Beijing Municipal Natural Science Foundation ; Beijing Municipal Natural Science Foundation
WOS记录号WOS:000269542700012
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59392
Collection北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Dept Antiinfect, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Beijing 100034, Peoples R China
4.Qianfoshan Hosp, Dept Gastroenterol, Jinan, Shandong, Peoples R China
5.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100037, Peoples R China
6.Peking Union Med Coll, Beijing 100021, Peoples R China
7.Peking Univ, Hosp 1, Dept Blood Transfus, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Cao, Bangwei,Liu, Xing,Hou, Fang,et al. The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population[J]. LIVER INTERNATIONAL,2009,29(9):1383-1388.
APA Cao, Bangwei.,Liu, Xing.,Hou, Fang.,Li, Wende.,Han, Zhonggang.,...&Qi, Huimin.(2009).The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population.LIVER INTERNATIONAL,29(9),1383-1388.
MLA Cao, Bangwei,et al."The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population".LIVER INTERNATIONAL 29.9(2009):1383-1388.
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