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Cyclovirobuxine D ameliorates acute myocardial ischemia by K-ATP channel opening, nitric oxide release and anti-thrombosis
Hu, Die; Liu, Xiaoyan; Wang, Yinye; Chen, Shizhong
关键词cyclovirobuxine D myocardial ischemia K-ATP NO cytoprotection antithrombus
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2007-08-13
DOI10.1016/j.ejphar.2007.04.038
569期:1-2页:103-109
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ISCHEMIA/REPERFUSION-INJURY ; ENDOTHELIAL-CELLS ; FAILURE ; ASSAY
英文摘要

Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia in China. The present study was to investigate its mechanism on myocardial ischemia. Cyclovirobuxine D significantly increased cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduced the infarct size induced by ligating the coronary artery in rats, and the effect was almost abolished by glibenclamide, a blocker of ATP sensitive potassium channel, but it was not influenced by cyclooxygenase-2 inhibitor celecoxib or estrogen receptor antagonist tamoxifen. In addition, cyclovirobuxine D significantly protected rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells, which was inhibited by nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME). Furthermore, cyclovirobuxine D significantly decreased the weight of venous thrombus in rats. In conclusion, the action mechanism of cyclovirobuxine D on myocardial ischemia may be related with its cytoprotection, K-ATP channel opening, NO generation stimulating and venous thrombosis inhibiting. (c) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000249085500015
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59398
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med Chem, Beijing 100083, Peoples R China
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GB/T 7714
Hu, Die,Liu, Xiaoyan,Wang, Yinye,et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K-ATP channel opening, nitric oxide release and anti-thrombosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,569(1-2):103-109.
APA Hu, Die,Liu, Xiaoyan,Wang, Yinye,&Chen, Shizhong.(2007).Cyclovirobuxine D ameliorates acute myocardial ischemia by K-ATP channel opening, nitric oxide release and anti-thrombosis.EUROPEAN JOURNAL OF PHARMACOLOGY,569(1-2),103-109.
MLA Hu, Die,et al."Cyclovirobuxine D ameliorates acute myocardial ischemia by K-ATP channel opening, nitric oxide release and anti-thrombosis".EUROPEAN JOURNAL OF PHARMACOLOGY 569.1-2(2007):103-109.
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