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学科主题: 药学
题名:
Cyclovirobuxine D ameliorates acute myocardial ischemia by K-ATP channel opening, nitric oxide release and anti-thrombosis
作者: Hu, Die; Liu, Xiaoyan; Wang, Yinye; Chen, Shizhong
关键词: cyclovirobuxine D ; myocardial ischemia ; K-ATP ; NO ; cytoprotection ; antithrombus
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2007-08-13
DOI: 10.1016/j.ejphar.2007.04.038
卷: 569, 期:1-2, 页:103-109
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ISCHEMIA/REPERFUSION-INJURY ; ENDOTHELIAL-CELLS ; FAILURE ; ASSAY
英文摘要:

Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia in China. The present study was to investigate its mechanism on myocardial ischemia. Cyclovirobuxine D significantly increased cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduced the infarct size induced by ligating the coronary artery in rats, and the effect was almost abolished by glibenclamide, a blocker of ATP sensitive potassium channel, but it was not influenced by cyclooxygenase-2 inhibitor celecoxib or estrogen receptor antagonist tamoxifen. In addition, cyclovirobuxine D significantly protected rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells, which was inhibited by nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME). Furthermore, cyclovirobuxine D significantly decreased the weight of venous thrombus in rats. In conclusion, the action mechanism of cyclovirobuxine D on myocardial ischemia may be related with its cytoprotection, K-ATP channel opening, NO generation stimulating and venous thrombosis inhibiting. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000249085500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59398
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med Chem, Beijing 100083, Peoples R China

Recommended Citation:
Hu, Die,Liu, Xiaoyan,Wang, Yinye,et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K-ATP channel opening, nitric oxide release and anti-thrombosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,569(1-2):103-109.
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