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学科主题: 口腔医学
题名:
Osteoblast adhesion to clodronate-hydroxyapatite composite
作者: Luo, E.1; Liu, X.1; Wei, S. C.2; Cai, X. X.1; Hu, J.1
关键词: Hydroxyapatite ; Osteoblast ; Adhesion ; Gene ; Surface modification
刊名: APPLIED SURFACE SCIENCE
发表日期: 2008-11-15
DOI: 10.1016/j.apsusc.2008.06.090
卷: 255, 期:2, 页:308-311
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Materials Science ; Physics
英文摘要:

The present study combined clodronate, one of bisphosphonates, to the surface of HA scaffold by chelation. The cell culture test and gene expression test were performed and evaluated the effect of clodronate modifying the HA on co-culturing osteoblast with HA scaffold in vitro. Characteristic peaks in XPS and FT-IR spectra indicated clodronate being immobilized on the surface of HA. The cell culture test indicated that the cells actively proliferated on the scaffolds. The results of RT-PCR showed there was no significant difference between two groups in expression of RANKL gene, while the expression of OPG gene showed higher expression in Clodronate-HA group. Clodronate had no obvious effect on the cytocompatibility of HA, and Clodronate-HA might be used as bone scaffold with potential ability to improve osteogenesis. (C) 2008 Elsevier B. V. All rights reserved.

语种: 英语
WOS记录号: WOS:000260510600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59400
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Sichuan Univ, State Key Lab Oral Dis, Chengdu 610044, Peoples R China
2.Peking Univ, Sch Stomatol, Beijing 100044, Peoples R China

Recommended Citation:
Luo, E.,Liu, X.,Wei, S. C.,et al. Osteoblast adhesion to clodronate-hydroxyapatite composite[J]. APPLIED SURFACE SCIENCE,2008,255(2):308-311.
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