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学科主题: 临床医学
题名:
Effect of Dalteparin on Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice
作者: Su, Lin1; Zhang, Qingwen1; Bao, Hui1; Li, Wei1; Miao, Yide1; Yan, Zheng2; Chen, Dingbao3
关键词: atherosclerosis ; dalteparin ; lectin-like oxidized LDL receptor 1
刊名: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
发表日期: 2015-04-01
DOI: 10.1177/1076029613499818
卷: 21, 期:3, 页:266-272
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: LOW-DENSITY-LIPOPROTEIN ; SMOOTH-MUSCLE-CELLS ; LECTIN-LIKE ; UNFRACTIONATED HEPARIN ; RECEPTOR-1 LOX-1 ; CRITICAL PLAYER ; PLAQUE RUPTURE ; EXPRESSION ; LDL ; ATHEROGENESIS
英文摘要:

We aimed to investigate whether prolonged treatment with dalteparin could inhibit plaque progression. With C57BL/6J mice as the control, genetically deficient apolipoprotein E (apo E) male mice of C57BL/6J strain (apo E-/-) were randomly divided into 3 groups. The model group received no dalteparin, while the other 2 groups received dalteparin at 100 and 200 U/kg d, respectively. The aorta was harvested for hematoxylin and eosin staining to observe plaque formation and for immunohistochemical staining to detect the expression of oxidized low-density lipoprotein receptor 1 (LOX-1). The expression of LOX-1 messenger RNA was detected by reverse transcription polymerase chain reaction, while the expression of LOX-1 protein was detected by Western blotting. Dalteparin decreased aortic plaque volume and inhibited aortic LOX-1 protein expression in apo E-/- mice. The effect persisted 4 weeks after dalteparin treatment was discontinued. Dalteparin may inhibit atherosclerotic lesions by downregulating the expression of LOX-1 protein.

语种: 英语
所属项目编号: RDB2007-19
项目资助者: Research and Development Fund of Peking University People&prime ; s Hospital
WOS记录号: WOS:000350492800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59407
Appears in Collections:北京大学第二临床医学院_老年科_期刊论文

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作者单位: 1.Peking Univ, Dept Geriatr, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Cent Lab, Peoples Hosp, Beijing 100044, Peoples R China
3.Peking Univ, Dept Pathol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Su, Lin,Zhang, Qingwen,Bao, Hui,et al. Effect of Dalteparin on Atherosclerotic Lesion Formation in Apolipoprotein E-Deficient Mice[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS,2015,21(3):266-272.
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