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学科主题: 临床医学
题名:
Species distribution and susceptibility of Candida isolates from patient with Vulvovaginal candidiasis in Southern China from 2003 to 2012
作者: Liu, X. P.1; Fan, S. R.2; Peng, Y. T.2; Zhang, H. P.2
关键词: Vulvovaginal candidiasis ; Candida species ; Susceptibility
刊名: JOURNAL DE MYCOLOGIE MEDICALE
发表日期: 2014-06-01
DOI: 10.1016/j.mycmed.2014.01.060
卷: 24, 期:2, 页:106-111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology
研究领域[WOS]: Mycology
关键词[WOS]: ANTIFUNGAL SUSCEPTIBILITIES ; VAGINITIS ; EPIDEMIOLOGY ; ALBICANS ; WOMEN
英文摘要:

Objective. - To determine the Candida species involved and the antifungal susceptibility of Candida species isolated from patients with vulvovaginal candidiasis (VVC).

Materials and methods. - Candida organisms were cultured from samples obtained from patients with VVC at Gynecology Department of Peking University Shenzhen Hospital from April 2003 to September 2012. Antifungal susceptibility testing was performed using a commercial agar diffusion test.

Results. - A total of 3181 yeasts isolates, mostly Candida, were obtained from 3141 patients with VVC. Two species of Candida were isolated from each of 40 patients (1.3%, 40/3141). C. albicans were the predominant Candida species (2705 strains, 85.0%) in VVC, followed by C. glabrata (337 strains, 10.6%), C. parapsilosis (49 strains, 1.5%), C. tropicalis (31 strains, 1.0%), Saccharomyces cerevisiae (23 strains, 0.7%), C. krusei (15 strains, 0.5%), Candida famata (11 strains, 0.4%), Rhodotorula sp. (6 strains, 0.2%), and C. lusitaniae (2 strains, 0.1%). Antifungal susceptibility was tested in a total of 1942 strains from patients with VVC. All of the C. albicans isolates obtained were susceptible to nystatin. The resistant rate of C. albicans to fluconazole, itraconazole, miconazole, clotrimazole was 1.1% (18/1612), 2.2% (36/1612), 4.2% (68/1612), and 0.9% (14/1612). The resistant rate of non-albicans to fluconazole, itraconazole, miconazole, and clotrimazole was 11.8% (39/329), 2.5% (8/329), 1.8% (6/329), and 4.3% (14/329).

Conclusions. - C. albicans was the predominant Candida species isolated from this series of patients with VVC. Resistance of vaginal C. albicans isolates to antifungal agents was infrequent. (C) 2014 Published by Elsevier Masson SAS.

语种: 英语
所属项目编号: 20120320020 ; ZDSY20120619145501681
项目资助者: Shenzhen Science and Technology
WOS记录号: WOS:000339983500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59420
Appears in Collections:北京大学深圳医院_检验科_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China

Recommended Citation:
Liu, X. P.,Fan, S. R.,Peng, Y. T.,et al. Species distribution and susceptibility of Candida isolates from patient with Vulvovaginal candidiasis in Southern China from 2003 to 2012[J]. JOURNAL DE MYCOLOGIE MEDICALE,2014,24(2):106-111.
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