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学科主题临床医学
Species distribution and susceptibility of Candida isolates from patient with Vulvovaginal candidiasis in Southern China from 2003 to 2012
Liu, X. P.1; Fan, S. R.2; Peng, Y. T.2; Zhang, H. P.2
关键词Vulvovaginal candidiasis Candida species Susceptibility
刊名JOURNAL DE MYCOLOGIE MEDICALE
2014-06-01
DOI10.1016/j.mycmed.2014.01.060
24期:2页:106-111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology
研究领域[WOS]Mycology
关键词[WOS]ANTIFUNGAL SUSCEPTIBILITIES ; VAGINITIS ; EPIDEMIOLOGY ; ALBICANS ; WOMEN
英文摘要

Objective. - To determine the Candida species involved and the antifungal susceptibility of Candida species isolated from patients with vulvovaginal candidiasis (VVC).

Materials and methods. - Candida organisms were cultured from samples obtained from patients with VVC at Gynecology Department of Peking University Shenzhen Hospital from April 2003 to September 2012. Antifungal susceptibility testing was performed using a commercial agar diffusion test.

Results. - A total of 3181 yeasts isolates, mostly Candida, were obtained from 3141 patients with VVC. Two species of Candida were isolated from each of 40 patients (1.3%, 40/3141). C. albicans were the predominant Candida species (2705 strains, 85.0%) in VVC, followed by C. glabrata (337 strains, 10.6%), C. parapsilosis (49 strains, 1.5%), C. tropicalis (31 strains, 1.0%), Saccharomyces cerevisiae (23 strains, 0.7%), C. krusei (15 strains, 0.5%), Candida famata (11 strains, 0.4%), Rhodotorula sp. (6 strains, 0.2%), and C. lusitaniae (2 strains, 0.1%). Antifungal susceptibility was tested in a total of 1942 strains from patients with VVC. All of the C. albicans isolates obtained were susceptible to nystatin. The resistant rate of C. albicans to fluconazole, itraconazole, miconazole, clotrimazole was 1.1% (18/1612), 2.2% (36/1612), 4.2% (68/1612), and 0.9% (14/1612). The resistant rate of non-albicans to fluconazole, itraconazole, miconazole, and clotrimazole was 11.8% (39/329), 2.5% (8/329), 1.8% (6/329), and 4.3% (14/329).

Conclusions. - C. albicans was the predominant Candida species isolated from this series of patients with VVC. Resistance of vaginal C. albicans isolates to antifungal agents was infrequent. (C) 2014 Published by Elsevier Masson SAS.

语种英语
WOS记录号WOS:000339983500005
项目编号20120320020 ; ZDSY20120619145501681
资助机构Shenzhen Science and Technology
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59420
专题北京大学深圳医院_检验科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Liu, X. P.,Fan, S. R.,Peng, Y. T.,et al. Species distribution and susceptibility of Candida isolates from patient with Vulvovaginal candidiasis in Southern China from 2003 to 2012[J]. JOURNAL DE MYCOLOGIE MEDICALE,2014,24(2):106-111.
APA Liu, X. P.,Fan, S. R.,Peng, Y. T.,&Zhang, H. P..(2014).Species distribution and susceptibility of Candida isolates from patient with Vulvovaginal candidiasis in Southern China from 2003 to 2012.JOURNAL DE MYCOLOGIE MEDICALE,24(2),106-111.
MLA Liu, X. P.,et al."Species distribution and susceptibility of Candida isolates from patient with Vulvovaginal candidiasis in Southern China from 2003 to 2012".JOURNAL DE MYCOLOGIE MEDICALE 24.2(2014):106-111.
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