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学科主题临床医学
Maturation and Emigration of Single-Positive Thymocytes
Xu, Xi1; Zhang, Shusong1; Li, Pingping1; Lu, Jin2; Xuan, Qun3; Ge, Qing1
刊名CLINICAL & DEVELOPMENTAL IMMUNOLOGY
2013
DOI10.1155/2013/282870
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]RECENT THYMIC EMIGRANTS ; T-CELL MATURATION ; MHC CLASS-II ; SPHINGOSINE 1-PHOSPHATE RECEPTOR ; PERIPHERAL LYMPHOID ORGANS ; TISSUE OXYGEN-TENSION ; NF-KAPPA-B ; DENDRITIC CELLS ; CENTRAL TOLERANCE ; IN-VIVO
英文摘要

T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are "fully mature" and waiting to be exported at random or follow a "first-in-first-out" manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.

语种英语
WOS记录号WOS:000325654300001
项目编号2010CB945301 ; 2011CB711000 ; 81372535 ; 31070787 ; 31270935 ; NCET-10-0175/BMU20100005 ; 20100001110049
资助机构Natural Basic Research Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59421
专题北京大学第二临床医学院_血液科
北京大学基础医学院
北京大学临床肿瘤学院_中西医结合科暨老年肿瘤科
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Dept Immunol,Key Lab Med Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100191, Peoples R China
3.Kunming Med Univ, Dept Microbiol & Immunol, Kunming, Peoples R China
推荐引用方式
GB/T 7714
Xu, Xi,Zhang, Shusong,Li, Pingping,et al. Maturation and Emigration of Single-Positive Thymocytes[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
APA Xu, Xi,Zhang, Shusong,Li, Pingping,Lu, Jin,Xuan, Qun,&Ge, Qing.(2013).Maturation and Emigration of Single-Positive Thymocytes.CLINICAL & DEVELOPMENTAL IMMUNOLOGY.
MLA Xu, Xi,et al."Maturation and Emigration of Single-Positive Thymocytes".CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013).
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