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学科主题: 临床医学
题名:
Maturation and Emigration of Single-Positive Thymocytes
作者: Xu, Xi1; Zhang, Shusong1; Li, Pingping1; Lu, Jin2; Xuan, Qun3; Ge, Qing1
刊名: CLINICAL & DEVELOPMENTAL IMMUNOLOGY
发表日期: 2013
DOI: 10.1155/2013/282870
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: RECENT THYMIC EMIGRANTS ; T-CELL MATURATION ; MHC CLASS-II ; SPHINGOSINE 1-PHOSPHATE RECEPTOR ; PERIPHERAL LYMPHOID ORGANS ; TISSUE OXYGEN-TENSION ; NF-KAPPA-B ; DENDRITIC CELLS ; CENTRAL TOLERANCE ; IN-VIVO
英文摘要:

T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are "fully mature" and waiting to be exported at random or follow a "first-in-first-out" manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.

语种: 英语
所属项目编号: 2010CB945301 ; 2011CB711000 ; 81372535 ; 31070787 ; 31270935 ; NCET-10-0175/BMU20100005 ; 20100001110049
项目资助者: Natural Basic Research Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000325654300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59421
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Dept Immunol,Key Lab Med Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100191, Peoples R China
3.Kunming Med Univ, Dept Microbiol & Immunol, Kunming, Peoples R China

Recommended Citation:
Xu, Xi,Zhang, Shusong,Li, Pingping,et al. Maturation and Emigration of Single-Positive Thymocytes[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
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