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学科主题临床医学
Madurella mycetomatis Is Highly Susceptible to Ravuconazole
Ahmed, Sarah Abdalla1,2,3; Kloezen, Wendy4; Duncanson, Frederick5; Zijlstra, Ed E.6; de Hoog, G. Sybren2,3,7,8,9,10,11; Fahal, Ahmed H.12; van de Sande, Wendy W. J.4
刊名PLOS NEGLECTED TROPICAL DISEASES
2014-06-01
DOI10.1371/journal.pntd.0002942
8期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Parasitology ; Tropical Medicine
研究领域[WOS]Infectious Diseases ; Parasitology ; Tropical Medicine
关键词[WOS]IN-VITRO ACTIVITIES ; MODIFIED NCCLS METHOD ; HYDROXIDE XTT ASSAY ; ANTIFUNGAL AGENTS ; TRIAZOLE ANTIFUNGAL ; CHAGAS-DISEASE ; ORAL TRIAZOLE ; BMS-207147 ; EFFICACY ; ASPERGILLOSIS
英文摘要

The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads to complications and unnecessary amputations, and its comparatively high cost in endemic areas. Hence, an effective and affordable drug is required to improve therapeutic outcome. E1224 is a potent orally available, broad-spectrum triazole currently being developed for the treatment of Chagas disease. E1224 is a prodrug that is rapidly converted to ravuconazole. Plasma levels of E1224 are low and transient, and its therapeutically active moiety, ravuconazole is therapeutically active. In the present study, the in vitro activity of ravuconazole against Madurella mycetomatis, the most common etiologic agent of eumycetoma, was evaluated and compared to that of ketoconazole and itraconazole. Ravuconazole showed excellent activity with MICs ranging between <= 0.002 and 0.031 mu g/ml, which were significantly lower than the MICs reported for ketoconazole and itraconazole. On the basis of our findings, E1224 with its resultant active moiety, ravuconazole, could be an effective and affordable therapeutic option for the treatment of eumycetoma.

语种英语
WOS记录号WOS:000338846100049
项目编号91611178
资助机构VENI of the Netherlands Organisation of Scientific Research (NWO)
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59422
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Centraalbureau Schimmelcultures CBS KNAW Fungal B, Utrecht, Netherlands
2.Univ Khartoum, Fac Med Lab Sci, Khartoum, Sudan
3.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands
4.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
5.Eisai Inc, Woodcliff Lake, NJ USA
6.Rotterdam Ctr Trop Med, Rotterdam, Netherlands
7.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.Second Mil Med Univ, Shanghai Inst Med Mycol, Changzheng Hosp, Shanghai, Peoples R China
10.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil
11.King Abdulassiz Univ, Jeddah, Saudi Arabia
12.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
推荐引用方式
GB/T 7714
Ahmed, Sarah Abdalla,Kloezen, Wendy,Duncanson, Frederick,et al. Madurella mycetomatis Is Highly Susceptible to Ravuconazole[J]. PLOS NEGLECTED TROPICAL DISEASES,2014,8(6).
APA Ahmed, Sarah Abdalla.,Kloezen, Wendy.,Duncanson, Frederick.,Zijlstra, Ed E..,de Hoog, G. Sybren.,...&van de Sande, Wendy W. J..(2014).Madurella mycetomatis Is Highly Susceptible to Ravuconazole.PLOS NEGLECTED TROPICAL DISEASES,8(6).
MLA Ahmed, Sarah Abdalla,et al."Madurella mycetomatis Is Highly Susceptible to Ravuconazole".PLOS NEGLECTED TROPICAL DISEASES 8.6(2014).
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