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学科主题: 临床医学
题名:
Madurella mycetomatis Is Highly Susceptible to Ravuconazole
作者: Ahmed, Sarah Abdalla1,2,3; Kloezen, Wendy4; Duncanson, Frederick5; Zijlstra, Ed E.6; de Hoog, G. Sybren2,3,7,8,9,10,11; Fahal, Ahmed H.12; van de Sande, Wendy W. J.4
刊名: PLOS NEGLECTED TROPICAL DISEASES
发表日期: 2014-06-01
DOI: 10.1371/journal.pntd.0002942
卷: 8, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Parasitology ; Tropical Medicine
研究领域[WOS]: Infectious Diseases ; Parasitology ; Tropical Medicine
关键词[WOS]: IN-VITRO ACTIVITIES ; MODIFIED NCCLS METHOD ; HYDROXIDE XTT ASSAY ; ANTIFUNGAL AGENTS ; TRIAZOLE ANTIFUNGAL ; CHAGAS-DISEASE ; ORAL TRIAZOLE ; BMS-207147 ; EFFICACY ; ASPERGILLOSIS
英文摘要:

The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads to complications and unnecessary amputations, and its comparatively high cost in endemic areas. Hence, an effective and affordable drug is required to improve therapeutic outcome. E1224 is a potent orally available, broad-spectrum triazole currently being developed for the treatment of Chagas disease. E1224 is a prodrug that is rapidly converted to ravuconazole. Plasma levels of E1224 are low and transient, and its therapeutically active moiety, ravuconazole is therapeutically active. In the present study, the in vitro activity of ravuconazole against Madurella mycetomatis, the most common etiologic agent of eumycetoma, was evaluated and compared to that of ketoconazole and itraconazole. Ravuconazole showed excellent activity with MICs ranging between <= 0.002 and 0.031 mu g/ml, which were significantly lower than the MICs reported for ketoconazole and itraconazole. On the basis of our findings, E1224 with its resultant active moiety, ravuconazole, could be an effective and affordable therapeutic option for the treatment of eumycetoma.

语种: 英语
所属项目编号: 91611178
项目资助者: VENI of the Netherlands Organisation of Scientific Research (NWO)
WOS记录号: WOS:000338846100049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59422
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Centraalbureau Schimmelcultures CBS KNAW Fungal B, Utrecht, Netherlands
2.Univ Khartoum, Fac Med Lab Sci, Khartoum, Sudan
3.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands
4.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
5.Eisai Inc, Woodcliff Lake, NJ USA
6.Rotterdam Ctr Trop Med, Rotterdam, Netherlands
7.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.Second Mil Med Univ, Shanghai Inst Med Mycol, Changzheng Hosp, Shanghai, Peoples R China
10.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil
11.King Abdulassiz Univ, Jeddah, Saudi Arabia
12.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan

Recommended Citation:
Ahmed, Sarah Abdalla,Kloezen, Wendy,Duncanson, Frederick,et al. Madurella mycetomatis Is Highly Susceptible to Ravuconazole[J]. PLOS NEGLECTED TROPICAL DISEASES,2014,8(6).
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