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学科主题: 临床医学
题名:
Expression of stromal derived factor-1 (SDF-1) and chemokine receptor (CXCR4) in bone metastasis of renal carcinoma
作者: Zhao, Fu-long; Guo, Wei
关键词: SDF-1/CXCR4 axis ; Chemokines ; Chemotaxis ; Renal carcinoma ; Bone metastases
刊名: MOLECULAR BIOLOGY REPORTS
发表日期: 2011-02-01
DOI: 10.1007/s11033-010-0200-5
卷: 38, 期:2, 页:1039-1045
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CELL LUNG-CANCER ; BREAST-CANCER ; PROSTATE-CANCER ; TUMOR-CELLS ; BIOLOGICAL AXIS ; PIVOTAL ROLE ; MIGRATION ; PROTEIN ; LIGAND ; GROWTH
英文摘要:

Renal cancer is a relatively common malignant carcinoma that metastasizes to bone. The chemokine stromal derived factor-1 (SDF-1) and its corresponding receptor CXCR4 have been shown to regulate organ-specific metastasis in other cancer types. Based on this observation, we predicted that the expressions of SDF-1 and CXCR4 play a role in renal carcinoma metastasis to bone. To investigate the expressions of SDF-1 and CXCR4, and to assess the correlation between SDF-1 and CXCR4 immunoreactivity in bone metastasis of renal carcinoma, we collected 10 in situ renal carcinoma samples and 30 bone metastasis samples. We analyzed SDF-1 and CXCR4 expression with immunohistochemical analysis on paraffin-embedded sections. Compared with primary renal carcinomas, the SDF-1 expression in bone metastases was significantly higher [80% (24/30) vs. 30% (3/10), P = 0.006]; the expression of CXCR4 was also higher [83.3% (25/30) vs. 40% (4/10), P = 0.014]. Pearson correlation analysis supports a positive correlation between SDF-1 and CXCR4 in bone metastasis of renal carcinoma. In addition, RT-PCR demonstrated that, as compared with in situ renal carcinoma tissues, SDF-1 expression was predominant in the bone metastasis samples (P = 0.001), while CXCR4 was overexpressed in the bone metastasis tissues (P = 0.028). Western blot analysis confirmed these trends. Our data suggest that the expression of SDF-1/CXCR4 is high in bone metastases and over-expression of SDF-1/CXCR4 may play important roles in the bone metastasis of renal carcinoma.

语种: 英语
所属项目编号: 20070001715 ; 2005-1009
项目资助者: Research Foundation for the Doctoral Program of Higher Education of China ; Capital Development and Research Foundation
WOS记录号: WOS:000286472600045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59426
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

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作者单位: Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Fu-long,Guo, Wei. Expression of stromal derived factor-1 (SDF-1) and chemokine receptor (CXCR4) in bone metastasis of renal carcinoma[J]. MOLECULAR BIOLOGY REPORTS,2011,38(2):1039-1045.
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