北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病理学系  > 期刊论文
学科主题: 基础医学
题名:
PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression
作者: Wan, Junhu1,2,3; Zhan, Jun1,2,3; Li, Shuai1,2,3; Ma, Ji1,2,3; Xu, Weizhi1,2,3; Liu, Chang1,2,3; Xue, Xiaowei1,2,3; Xie, Yuping4; Fang, Weigang1,2,5; Chin, Y. Eugene6; Zhang, Hongquan1,2,3
刊名: NUCLEIC ACIDS RESEARCH
发表日期: 2015-04-20
DOI: 10.1093/nar/gkv238
卷: 43, 期:7, 页:3591-3604
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: HISTONE METHYLTRANSFERASE ACTIVITY ; H3 LYSINE-27 METHYLATION ; PROSTATE-CANCER ; STEM-CELLS ; SUPPRESSES METHYLATION ; POLYCOMB ; PHOSPHORYLATION ; PROTEIN ; DIFFERENTIATION ; GENE
英文摘要:

Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator that catalyzes the trimethylation of H3K27 and is modulated by post-translational modifications (PTMs). However, the precise regulation of EZH2 PTMs remains elusive. We, herein, report that EZH2 is acetylated by acetyltransferase P300/CBP-associated factor (PCAF) and is deacetylated by deacetylase SIRT1. We identified that PCAF interacts with and acetylates EZH2 mainly at lysine 348 (K348). Mechanistically, K348 acetylation decreases EZH2 phosphorylation at T345 and T487 and increases EZH2 stability without disrupting the formation of polycomb repressive complex 2 (PRC2). Functionally, EZH2 K348 acetylation enhances its capacity in suppression of the target genes and promotes lung cancer cell migration and invasion. Further, elevated EZH2 K348 acetylation in lung adenocarcinoma patients predicts a poor prognosis. Our findings define a new mechanism underlying EZH2 modulation by linking EZH2 acetylation to its phosphorylation that stabilizes EZH2 and promotes lung adenocarcinoma progression.

语种: 英语
所属项目编号: 2015CB553906 ; 2013CB910501 ; 2013ZX09401004-006 ; 81230051 ; 30830048 ; 31170711 ; 81321003 ; 7120002 ; BMU20120314 ; BMU20130364
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; 111 Project of the Ministry of Education ; Beijing Natural Science Foundation ; Peking University ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号: WOS:000354722500022
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59429
Appears in Collections:基础医学院_病理学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression.pdf(15862KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Lab Mol Cell Biol & Tumor Biol, Dept Anat Histol & Embrol, Beijing 100191, Peoples R China
5.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
6.Chinese Acad Sci, Shanghai Jiao Tong Univ, Sch Med, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China

Recommended Citation:
Wan, Junhu,Zhan, Jun,Li, Shuai,et al. PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression[J]. NUCLEIC ACIDS RESEARCH,2015,43(7):3591-3604.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wan, Junhu]'s Articles
[Zhan, Jun]'s Articles
[Li, Shuai]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wan, Junhu]‘s Articles
[Zhan, Jun]‘s Articles
[Li, Shuai]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace