北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Changes in arterial hydrogen sulfide (H2S) content during septic shock and endotoxin shock in rats
作者: Hui, Y; Du, JB; Tang, CS; Bin, G; Jiang, HF
关键词: hydrogen sulfide ; shock ; nitric oxide ; artery ; blood pressure
刊名: JOURNAL OF INFECTION
发表日期: 2003-08-01
DOI: 10.1016/S0163-4453(03)00043-4
卷: 47, 期:2, 页:155-160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: NITRIC-OXIDE
英文摘要:

Objectives: To explore the changes of hydrogen sulfide (H2S) in vascular tissues of rats with septic shock and endotoxin shock and its possible pathophysiological implication. Methods: Rat models of septic shock induced by cecal Ligation and puncture and of endotoxic shock induced by injection of endotoxin were used in this study. The authors measured hymodynamic variations, metabolic data, H2S and nitric oxide (NO) contents of different arteries in rats with septic shock and endotoxic shock. Results: The results showed that hemodynamic parameters including the heart rate (HR), the mean arterial pressure (BP), and the +dP/dt max decreased markedly, while the left ventricular end-diastolic pressure (LVEDP) increased significantly and the rats H2S contents were significantly developed hypoglycemia and lactic acidosis. Arterial H increased (P < 0.01) in both septic and endotoxic shock (P < 0.01). Endogenous H2S and NO contents all negatively correlated with BP, cardiac function and the degree of hypoglycemia (P < 0.01). Conclusions: The results of our study demonstrated that endogenous vascular H2S increased in rats with septic shock and endotoxic shock. It was suggested that endogenous H2S was involved in physiological and pathophysiotogical process during shock. (C) 2003 The British Infection Society. Published by Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000184302600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59430
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China

Recommended Citation:
Hui, Y,Du, JB,Tang, CS,et al. Changes in arterial hydrogen sulfide (H2S) content during septic shock and endotoxin shock in rats[J]. JOURNAL OF INFECTION,2003,47(2):155-160.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hui, Y]'s Articles
[Du, JB]'s Articles
[Tang, CS]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hui, Y]‘s Articles
[Du, JB]‘s Articles
[Tang, CS]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace