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Changes in arterial hydrogen sulfide (H2S) content during septic shock and endotoxin shock in rats
Hui, Y; Du, JB; Tang, CS; Bin, G; Jiang, HF
关键词hydrogen sulfide shock nitric oxide artery blood pressure
刊名JOURNAL OF INFECTION
2003-08-01
DOI10.1016/S0163-4453(03)00043-4
47期:2页:155-160
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]NITRIC-OXIDE
英文摘要

Objectives: To explore the changes of hydrogen sulfide (H2S) in vascular tissues of rats with septic shock and endotoxin shock and its possible pathophysiological implication. Methods: Rat models of septic shock induced by cecal Ligation and puncture and of endotoxic shock induced by injection of endotoxin were used in this study. The authors measured hymodynamic variations, metabolic data, H2S and nitric oxide (NO) contents of different arteries in rats with septic shock and endotoxic shock. Results: The results showed that hemodynamic parameters including the heart rate (HR), the mean arterial pressure (BP), and the +dP/dt max decreased markedly, while the left ventricular end-diastolic pressure (LVEDP) increased significantly and the rats H2S contents were significantly developed hypoglycemia and lactic acidosis. Arterial H increased (P < 0.01) in both septic and endotoxic shock (P < 0.01). Endogenous H2S and NO contents all negatively correlated with BP, cardiac function and the degree of hypoglycemia (P < 0.01). Conclusions: The results of our study demonstrated that endogenous vascular H2S increased in rats with septic shock and endotoxic shock. It was suggested that endogenous H2S was involved in physiological and pathophysiotogical process during shock. (C) 2003 The British Infection Society. Published by Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000184302600010
引用统计
被引频次:83[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59430
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Hui, Y,Du, JB,Tang, CS,et al. Changes in arterial hydrogen sulfide (H2S) content during septic shock and endotoxin shock in rats[J]. JOURNAL OF INFECTION,2003,47(2):155-160.
APA Hui, Y,Du, JB,Tang, CS,Bin, G,&Jiang, HF.(2003).Changes in arterial hydrogen sulfide (H2S) content during septic shock and endotoxin shock in rats.JOURNAL OF INFECTION,47(2),155-160.
MLA Hui, Y,et al."Changes in arterial hydrogen sulfide (H2S) content during septic shock and endotoxin shock in rats".JOURNAL OF INFECTION 47.2(2003):155-160.
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