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学科主题: 临床医学
题名:
Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China
作者: An, Shuchang1; Chen, Jichao2; Wang, Zhanwei3; Wang, Xiaorong1; Yan, Xixin4; Li, Jihong5; Chen, Yusheng6; Wang, Qi7; Xu, Xiaoling8; Li, Jiabin9; Yang, Jingping10; Wang, Hui3; Gao, Zhancheng1
关键词: extended-spectrum ss-lactamase ; CTX-M ; Klebsiella pneumoniae ; multilocus sequence typing
刊名: FEMS MICROBIOLOGY LETTERS
发表日期: 2012-07-01
DOI: 10.1111/j.1574-6968.2012.02586.x
卷: 332, 期:2, 页:137-145
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: SPECTRUM BETA-LACTAMASES ; ESCHERICHIA-COLI ; GENOTYPE DISTRIBUTION ; ENTEROBACTERIACEAE ; STRAINS ; SPREAD ; CTX-M-15 ; OUTBREAK ; SHV-11
英文摘要:

From February 2010 to July 2011, 183 of 416 presumptive Klebsiella pneumoniae isolates with reduced susceptibility to third-generation cephalosporins from patients with lower respiratory tract infection were collected from seven tertiary hospitals in China. Phenotypic and genotypic methods were employed to characterize 158 extended-spectrum beta-lactamase (ESBL)-producers. Among the 158 isolates analyzed, 134 (84.8%) harbored blaCTX-M, within which the most predominant ESBL gene was CTX-M-14 (49.4%), followed by CTX-M-15 (12.0%) and CTX-M-27 (10.8%). Also, 120 (75.9%) harbored blaSHV. One novel SHV variant, blaSHV-142 with T18A and L35Q substitutions, was identified. Ninety-one isolates carried blaTEM-1. An isolate containing blaTEM-135 was first identified in Klebsiella spp. blaKPC-2 was detected in 5 isolates. More than one ESBL combination was detected in 18 isolates (11.4%). Fifty-four (34.2%) isolates demonstrated the multidrug resistant (MDR) phenotype. Seventy-four sequence types (STs) were identified, which showed large genetic background diversity in ESBL-producing K.pneumoniae isolates from the six areas. This is the first report on the high prevalence of CTX-M-27 in China with the possible transmission of a single clone (ST48). The correlated surveillance of organisms with MDR phenotype should be investigated in future.

语种: 英语
WOS记录号: WOS:000305334300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59431
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.China Aerosp Corp, Cent Hosp, Dept Resp Med, Beijing, Peoples R China
2.Fujian Prov Hosp, Dept Resp Med, Fuzhou, Peoples R China
3.Anhui Prov Hosp, Dept Resp Med, Hefei, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
6.Hebei Med Univ, Hosp 2, Dept Resp Med, Shijiazhuang, Peoples R China
7.Hebei Med Univ, Hosp 2, Dept Clin Lab, Shijiazhuang, Peoples R China
8.Dalian Med Univ, Affiliated Hosp 2, Dept Resp Med, Dalian, Peoples R China
9.Anhui Med Univ, Affiliated Hosp 1, Dept Infect Dis, Hefei, Peoples R China
10.Inner Mongolia Med Coll, Affiliated Hosp 3, Dept Resp Med, Baotou, Peoples R China

Recommended Citation:
An, Shuchang,Chen, Jichao,Wang, Zhanwei,et al. Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China[J]. FEMS MICROBIOLOGY LETTERS,2012,332(2):137-145.
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