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学科主题: 临床医学
题名:
Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome
作者: Chen, Li1; Wang, Li2; Sun, Jinghui3; Qin, Jiong1; Tang, Chaoshu2,4; Jin, Hongfang1; Du, Junbao1
关键词: Children ; Midodrine ; Metoprolol ; Postural orthostatic tachycardia syndrome
刊名: CIRCULATION JOURNAL
发表日期: 2011-04-01
DOI: 10.1253/circj.CJ-10-0514
卷: 75, 期:4, 页:927-931
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: INTOLERANCE ; MANAGEMENT ; DIAGNOSIS
英文摘要:

Background: The study was carried out to examine the effect of selective alpha 1 adrenoceptor agonist midodrine hydrochloride vs. beta-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS).

Methods and Results: Fifty-three children with POTS were divided into group I (midodrine hydrochloride plus conventional therapy), group II (metoprolol plus conventional therapy) and group III (conventional therapy). Standing test was conducted for all participants. The cure rate, improvement rate, effective rate and score of symptoms were compared among the 3 groups. A Kaplan-Meier survivorship curve was used to describe the proportion of symptom-free cases during a long term follow-up. The cure rate and effective rate at the end of short term follow-up in group I were significantly higher than those of group II and group III (68.42% vs. 42.11% vs. 20.00%, P<0.05; 89.47% vs. 57.89% vs. 53.33%, P<0.05). After treatment, the symptom score in group I was significantly lower than group II and group III, respectively (1.1 +/- 2.2 vs. 2.8 +/- 2.4 vs. 3.7 +/- 2.0, P<0.05), and it also had significant difference between group II and group III (P<0.05). The symptom recurrent rate in group I was significantly lower than that of group II and group III, respectively (P<0.05), but it did not differ between group II and group III (P>0.05).

Conclusions: Midodrine hydrochloride is effective in the treatment of children with POTS. (Circ J 2011; 75: 927-931)

语种: 英语
所属项目编号: D10100050010059 ; 30821001
项目资助者: Beijing Science and Technology Plan ; Capital Medical Development Scientific Project ; National Natural Science Foundation of China
WOS记录号: WOS:000289024600030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59434
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab, Beijing, Peoples R China
3.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
4.Jilin Univ, Dept Pediat, Hosp 1, Changchun 130023, Peoples R China

Recommended Citation:
Chen, Li,Wang, Li,Sun, Jinghui,et al. Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome[J]. CIRCULATION JOURNAL,2011,75(4):927-931.
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