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学科主题临床医学
Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome
Chen, Li1; Wang, Li2; Sun, Jinghui3; Qin, Jiong1; Tang, Chaoshu2,4; Jin, Hongfang1; Du, Junbao1
关键词Children Midodrine Metoprolol Postural orthostatic tachycardia syndrome
刊名CIRCULATION JOURNAL
2011-04-01
DOI10.1253/circj.CJ-10-0514
75期:4页:927-931
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]INTOLERANCE ; MANAGEMENT ; DIAGNOSIS
英文摘要

Background: The study was carried out to examine the effect of selective alpha 1 adrenoceptor agonist midodrine hydrochloride vs. beta-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS).

Methods and Results: Fifty-three children with POTS were divided into group I (midodrine hydrochloride plus conventional therapy), group II (metoprolol plus conventional therapy) and group III (conventional therapy). Standing test was conducted for all participants. The cure rate, improvement rate, effective rate and score of symptoms were compared among the 3 groups. A Kaplan-Meier survivorship curve was used to describe the proportion of symptom-free cases during a long term follow-up. The cure rate and effective rate at the end of short term follow-up in group I were significantly higher than those of group II and group III (68.42% vs. 42.11% vs. 20.00%, P<0.05; 89.47% vs. 57.89% vs. 53.33%, P<0.05). After treatment, the symptom score in group I was significantly lower than group II and group III, respectively (1.1 +/- 2.2 vs. 2.8 +/- 2.4 vs. 3.7 +/- 2.0, P<0.05), and it also had significant difference between group II and group III (P<0.05). The symptom recurrent rate in group I was significantly lower than that of group II and group III, respectively (P<0.05), but it did not differ between group II and group III (P>0.05).

Conclusions: Midodrine hydrochloride is effective in the treatment of children with POTS. (Circ J 2011; 75: 927-931)

语种英语
WOS记录号WOS:000289024600030
项目编号D10100050010059 ; 30821001
资助机构Beijing Science and Technology Plan ; Capital Medical Development Scientific Project ; National Natural Science Foundation of China
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59434
专题北京大学第一临床医学院_儿科
北京大学第二临床医学院_儿科
作者单位1.Peking Univ, Hlth Sci Ctr, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab, Beijing, Peoples R China
3.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
4.Jilin Univ, Dept Pediat, Hosp 1, Changchun 130023, Peoples R China
推荐引用方式
GB/T 7714
Chen, Li,Wang, Li,Sun, Jinghui,et al. Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome[J]. CIRCULATION JOURNAL,2011,75(4):927-931.
APA Chen, Li.,Wang, Li.,Sun, Jinghui.,Qin, Jiong.,Tang, Chaoshu.,...&Du, Junbao.(2011).Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome.CIRCULATION JOURNAL,75(4),927-931.
MLA Chen, Li,et al."Midodrine Hydrochloride Is Effective in the Treatment of Children With Postural Orthostatic Tachycardia Syndrome".CIRCULATION JOURNAL 75.4(2011):927-931.
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