学科主题基础医学
Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats
Yuan, Ying2; Wang, Xi3; Zeng, Qiang1; Wu, Hong-Mei3; Qi, Yong-Fen4,5; Tang, Chao-Shu4,5
关键词Intermedin Receptor activity-modifying proteins Calcitonin receptor-like receptor Mini-osmotic pumps Hemodynamic parameters Spontaneously hypertensive rats
刊名JOURNAL OF GERIATRIC CARDIOLOGY
2012
DOI10.3724/SP.J.1263.2012.00017
9期:1页:17-27
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]GENE-RELATED PEPTIDE ; LEFT-VENTRICULAR HYPERTROPHY ; MODIFYING PROTEINS RAMPS ; CENTRAL-NERVOUS-SYSTEM ; RECEPTOR-LIKE RECEPTOR ; HEART-FAILURE ; CONSCIOUS RATS ; FAMILY PEPTIDE ; UP-REGULATION ; ADRENOMEDULLIN
英文摘要

Objective To examine the effects of exogenously administered intermedin (IMD, adrenomedullin-2) on arterial blood pressure, cardiac function and the cardiovascular IMD receptor system in spontaneously hypertensive rats (SHRs) as well as to investigate the associated mechanisms. Methods Thirteen week-old male rats were divided in Wistar Kyoto (WKY) group (n = 12), SHR group (n = 12), IMD group (SHRs infused with IMD 1-47 500 ng/kg per hour, n = 12), and ADM group (SHRs infused with adrenomedullin 500 ng/kg per hour, n = 12). Results A two-week continuous administration of low dose IMD 1-47 via mini-osmotic pumps markedly reduced blood pressure, the maximal rates of increase and decrease of left-ventricle pressure development (LV +/- dp/dt(max)), left ventricular systolic pressure and heart rate in SHRs. Furthermore, IMD also inhibited protein over-expression of cardiovascular IMD receptors, myocardial Receptor Activity-Modifying Proteins (RAMP1 and RAMP2), aortic RAMP1, RAMP2, RAMP3, and calcitonin receptor-like receptor (CRLR); suppressed up-regulation of aortic RAMP1, RAMP2, RAMP3 and CRLR gene expression; and markedly elevated the mRNA abundance of myocardial atrial natriuretic peptide (ANP) and myocardial brain natriuretic peptide (BNP). Additionally, IMD 1-47 administration in SHRs increased aortic cAMP concentration and reduced myocardial cAMP concentration. Conclusion These findings support the speculation that IMD, as a cardiovascular active peptide, is involved in blood pressure reduction and cardiac function amelioration during hypertension. The mechanism underlying this effect may involve IMD binding of a receptor complex formed by RAMPs and CRLR, and consequential regulation of cAMP levels and other cardiovascular active factors, such as ANP and BNP.

语种英语
WOS记录号WOS:000301520300005
项目编号30570738 ; NCET-05-0016
资助机构National Natural Sciences Foundation of China ; University of the Education Ministry of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59439
专题北京大学基础医学院_生理学与病理生理学系
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Int Med Ctr, Beijing 100853, Peoples R China
2.Inst Aviat Med, Human Centrifuge Med Training Base, Beijing 100089, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China
5.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
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GB/T 7714
Yuan, Ying,Wang, Xi,Zeng, Qiang,et al. Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2012,9(1):17-27.
APA Yuan, Ying,Wang, Xi,Zeng, Qiang,Wu, Hong-Mei,Qi, Yong-Fen,&Tang, Chao-Shu.(2012).Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats.JOURNAL OF GERIATRIC CARDIOLOGY,9(1),17-27.
MLA Yuan, Ying,et al."Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats".JOURNAL OF GERIATRIC CARDIOLOGY 9.1(2012):17-27.
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