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学科主题: 临床医学
题名:
Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens
作者: Yong-gang, Cao1; Shan, Jing2; Lei, Li3; Jing-quan, Gao4; Zhi-ying, Shen5; Yan, Liu6; Yan, Xing1; Ming-li, Wu1; Ye, Wang1; Chang-qing, Xu7; Hong-li, Sun1
关键词: oxymatrine ; arrhythmia ; APD ; ion channel
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2010-12-01
DOI: 10.1002/ptr.3206
卷: 24, 期:12, 页:1844-1849
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: VENTRICULAR ARRHYTHMIAS ; MYOCARDIAL-ISCHEMIA ; INFARCTION ; CHANNELS
英文摘要:

Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular system. This study was designed to evaluate the antiarrhythmic effects as well as the electrophysiological properties of oxymatrine. The antiarrhythmic activity of oxymatrine was observed in a rat model of arrhythmia induced by coronary ligation. Action potential duration (APD), L-type calcium current (I(Ca-L)), transient outward potassium current (I(t0)) and inward rectifier potassium current (I(K1)) in rat ventricular myocytes were recorded by utilizing the whole cell patch-clamp technique. The results showed that administration of oxymatrine significantly delayed the onset of ventricular arrhythmia, decreased the duration of ventricular arrhythmia and reduced the arrhythmia score of arrhythmic rats. The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of I(Ca-L), enhancement of I(t0) and inhibition of I(K1). Copyright (C) 2010 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: D200960 ; 11531082
项目资助者: Natural Science Foundation of Heilongjiang Province of China ; Education Department of Heilongjiang Province of China
WOS记录号: WOS:000285679200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59448
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Harbin Med Coll, Dept Pharmacol, Daqing 163319, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
3.Harbin Med Coll, Clin Coll 5, Dept Surg, Daqing 163316, Peoples R China
4.Harbin Med Coll, Dept Clin Nursing, Daqing 163319, Peoples R China
5.Harbin Med Coll, Dept Pharmaceut Bot, Daqing 163319, Peoples R China
6.Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China
7.Harbin Med Coll, Dept Pathophysiol, Harbin 150081, Peoples R China

Recommended Citation:
Yong-gang, Cao,Shan, Jing,Lei, Li,et al. Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens[J]. PHYTOTHERAPY RESEARCH,2010,24(12):1844-1849.
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