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学科主题临床医学
Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens
Yong-gang, Cao1; Shan, Jing2; Lei, Li3; Jing-quan, Gao4; Zhi-ying, Shen5; Yan, Liu6; Yan, Xing1; Ming-li, Wu1; Ye, Wang1; Chang-qing, Xu7; Hong-li, Sun1
关键词oxymatrine arrhythmia APD ion channel
刊名PHYTOTHERAPY RESEARCH
2010-12-01
DOI10.1002/ptr.3206
24期:12页:1844-1849
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]VENTRICULAR ARRHYTHMIAS ; MYOCARDIAL-ISCHEMIA ; INFARCTION ; CHANNELS
英文摘要

Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular system. This study was designed to evaluate the antiarrhythmic effects as well as the electrophysiological properties of oxymatrine. The antiarrhythmic activity of oxymatrine was observed in a rat model of arrhythmia induced by coronary ligation. Action potential duration (APD), L-type calcium current (I(Ca-L)), transient outward potassium current (I(t0)) and inward rectifier potassium current (I(K1)) in rat ventricular myocytes were recorded by utilizing the whole cell patch-clamp technique. The results showed that administration of oxymatrine significantly delayed the onset of ventricular arrhythmia, decreased the duration of ventricular arrhythmia and reduced the arrhythmia score of arrhythmic rats. The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of I(Ca-L), enhancement of I(t0) and inhibition of I(K1). Copyright (C) 2010 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000285679200014
项目编号D200960 ; 11531082
资助机构Natural Science Foundation of Heilongjiang Province of China ; Education Department of Heilongjiang Province of China
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59448
专题北京大学第二临床医学院_心血管内科
作者单位1.Harbin Med Coll, Dept Pharmacol, Daqing 163319, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
3.Harbin Med Coll, Clin Coll 5, Dept Surg, Daqing 163316, Peoples R China
4.Harbin Med Coll, Dept Clin Nursing, Daqing 163319, Peoples R China
5.Harbin Med Coll, Dept Pharmaceut Bot, Daqing 163319, Peoples R China
6.Harbin Med Coll, Dept Pharmacol, Harbin 150081, Peoples R China
7.Harbin Med Coll, Dept Pathophysiol, Harbin 150081, Peoples R China
推荐引用方式
GB/T 7714
Yong-gang, Cao,Shan, Jing,Lei, Li,et al. Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens[J]. PHYTOTHERAPY RESEARCH,2010,24(12):1844-1849.
APA Yong-gang, Cao.,Shan, Jing.,Lei, Li.,Jing-quan, Gao.,Zhi-ying, Shen.,...&Hong-li, Sun.(2010).Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens.PHYTOTHERAPY RESEARCH,24(12),1844-1849.
MLA Yong-gang, Cao,et al."Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens".PHYTOTHERAPY RESEARCH 24.12(2010):1844-1849.
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