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学科主题: 临床医学
题名:
Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis
作者: Zhao, Jinxia; Zhao, Yi; He, Jing; Jia, Rulin; Li, Zhanguo
关键词: peptidylarginine deiminase ; citrulline ; antibodies ; rheumatoid arthritis
刊名: JOURNAL OF RHEUMATOLOGY
发表日期: 2008-06-01
卷: 35, 期:6, 页:969-974
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: PADI4 GENE ; AUTOANTIBODIES ; ASSOCIATION ; POPULATION ; CITRULLINE ; DISEASE ; ENZYME ; FAMILY
英文摘要:

Objective. To detect anti-peptidylarginine deiminase 4 (PAD4) antibody in patients with rheumatoid arthritis (RA) and to investigate its clinical significance in the pathogenesis of RA.

Methods. Serum samples were obtained from 109 patients with RA, 67 systemic lupus erythematosus (SLE), 48 primary Sjogren′s syndrome (pSS), 41 systemic sclerosis (SSc), 34 osteoarthritis (OA), 23 dermatomyositis/polymyositis (DM/PM), and 19 ankylosing spondylitis (AS) and 106 healthy individuals. The presence of antibodies against recombinant human PAD4 (anti-PAD4) was examined by ELISA. Associations between anti-PAD4 and the clinical features of RA were evaluated.

Results. The prevalence of anti-PAD4 in RA patients (45.0%) was significantly higher than those of SLE (9.0%), pSS (4.2%), SSc (9.8%), OA (5.9%), DM/PM (13.0%), AS (0%), and controls (4.7%). The mean titer of anti-PAD4 in RA was also significantly higher than in SLE, other rheumatic diseases, and controls. Disease Activity Score-28 (DAS28), anti-cyclic citrullinated peptide (CCP) antibody, erythrocyte sedimentation rate, rheumatoid factor, IgM, and IgG in anti-PAD4-positive patients were all higher than in anti-PAD4-negative patients. There were positive correlations between anti-PAD4 and DAS28 score (r = 0.333, p < 0.01) and anti-CCP antibody (r = 0.248, p < 0.05).

Conclusion. The presence of anti-PAD4 in RA indicates that PAD4 may act as an autoantigen that may play a role in the pathogenesis of RA.

语种: 英语
WOS记录号: WOS:000256503900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59450
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Jinxia,Zhao, Yi,He, Jing,et al. Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis[J]. JOURNAL OF RHEUMATOLOGY,2008,35(6):969-974.
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