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学科主题基础医学
ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells
Wang, Hongjie; Lin, Guiting; Zhang, Zhiwen
关键词ATF5 Hsp27 heat shock cell survival transcription
刊名CELL BIOLOGY INTERNATIONAL
2007-11-01
DOI10.1016/j.cellbi.2007.05.002
31期:11页:1309-1315
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]NEURAL PROGENITOR CELLS ; HEAT-SHOCK PROTEINS ; MYOCARDIAL-INFARCTION ; ATF/CREB FAMILY ; GENE-EXPRESSION ; HEAT-SHOCK-PROTEIN-27 ; APOPTOSIS ; PROTECTS ; DIFFERENTIATION ; IDENTIFICATION
英文摘要

The activating transcription factor (ATF) family comprises a group of basic region-leucine zipper (bZIP) proteins, which have roles in development, differentiation, proliferation and apoptosis. Here we described that ATF5 could promote cell survival in heat shock stress and identified that heat shock protein 27 (Hsp27) as one of its target gene related to cell survival. The ectopic expression of ATF5 could significantly increase cell tolerance to elevated temperature and the CRE motif played an important role in upregulating Hsp27 gene promoter activity by ATF5. Also, inhibition of Hsp27 expression by RNAi could increase cell death in ATF5 ectopic expressing cells, indicating that Hsp27 involved in ATF5 mediated cell survival. Taken together, our results indicated that ATF5 promoted H9c2 cell survival in heat shock stress at least through activation of Hsp27. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000249610600003
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59453
专题北京大学基础医学院
作者单位Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
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Wang, Hongjie,Lin, Guiting,Zhang, Zhiwen. ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells[J]. CELL BIOLOGY INTERNATIONAL,2007,31(11):1309-1315.
APA Wang, Hongjie,Lin, Guiting,&Zhang, Zhiwen.(2007).ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells.CELL BIOLOGY INTERNATIONAL,31(11),1309-1315.
MLA Wang, Hongjie,et al."ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells".CELL BIOLOGY INTERNATIONAL 31.11(2007):1309-1315.
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