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学科主题: 基础医学
题名:
ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells
作者: Wang, Hongjie; Lin, Guiting; Zhang, Zhiwen
关键词: ATF5 ; Hsp27 ; heat shock ; cell survival ; transcription
刊名: CELL BIOLOGY INTERNATIONAL
发表日期: 2007-11-01
DOI: 10.1016/j.cellbi.2007.05.002
卷: 31, 期:11, 页:1309-1315
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: NEURAL PROGENITOR CELLS ; HEAT-SHOCK PROTEINS ; MYOCARDIAL-INFARCTION ; ATF/CREB FAMILY ; GENE-EXPRESSION ; HEAT-SHOCK-PROTEIN-27 ; APOPTOSIS ; PROTECTS ; DIFFERENTIATION ; IDENTIFICATION
英文摘要:

The activating transcription factor (ATF) family comprises a group of basic region-leucine zipper (bZIP) proteins, which have roles in development, differentiation, proliferation and apoptosis. Here we described that ATF5 could promote cell survival in heat shock stress and identified that heat shock protein 27 (Hsp27) as one of its target gene related to cell survival. The ectopic expression of ATF5 could significantly increase cell tolerance to elevated temperature and the CRE motif played an important role in upregulating Hsp27 gene promoter activity by ATF5. Also, inhibition of Hsp27 expression by RNAi could increase cell death in ATF5 ectopic expressing cells, indicating that Hsp27 involved in ATF5 mediated cell survival. Taken together, our results indicated that ATF5 promoted H9c2 cell survival in heat shock stress at least through activation of Hsp27. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000249610600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59453
Appears in Collections:基础医学院_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Hongjie,Lin, Guiting,Zhang, Zhiwen. ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells[J]. CELL BIOLOGY INTERNATIONAL,2007,31(11):1309-1315.
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