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学科主题: 口腔医学
题名:
Prognostic Factors of Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Study of 168 Cases in North China
作者: Niu, Li Xuan; Feng, Zhien; Li, Jian Nan; Li, Chuan Zhen; Peng, Xin; Guo, Chuan Bin
刊名: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
发表日期: 2014-11-01
DOI: 10.1016/j.joms.2014.05.021
卷: 72, 期:11, 页:2344-2350
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: NECK DISSECTION ; LOCAL-CONTROL ; ORAL-CAVITY ; CANCER ; TAIWAN
英文摘要:

Purpose: Buccal mucosa squamous cell carcinoma (BSCC) is considered a rare and aggressive malignancy that has a high rate of locoregional recurrence. The aim of this study was to analyze the outcome of surgical therapy as a treatment for BSCC in a North Chinese population over a period of 14 years.

Materials and Methods: A retrospective study was performed by reviewing the records and pathologies of 168 patients with BSCC who were treated at the Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Peking University, from June 1999 to September 2013.

Results: The rates of local, regional, and locoregional recurrence were 47.3%, 13.5%, and 6.8%, respectively. The neck metastasis rate in patients classified as having cN0 was 28.4%, and the occult metastasis rate in patients with BSCC stages T2 to T4 was higher than 15%. Neck metastases were most common at levels I and II. The 3-year disease-free survival, overall survival, and disease-specific survival rates were 60.6%, 74.6%, and 78.0%, respectively. Gender, T stage, pathologic node status, and pathologic grade were significant factors in determining disease-specific survival. However, only pathologic node status (P =.002) was an independent predictive factor of 3-year disease-specific survival.

Conclusions: Buccal carcinoma is an aggressive disease with high rates of local and regional recurrence. In seeking to offer better prognoses and quality of life, extensive resection of the primary tumor, supraomohyoid neck dissection, and preferred free flap reconstruction are the therapies that have been recommended and used in the authors′ hospital during the past 10 years. (C) 2014 American Association of Oral and Maxillofacial Surgeons

语种: 英语
所属项目编号: 81302350 ; 7144258 ; 2013M530495 ; 2009AA045201
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; China Postdoctoral Science Foundation ; National High Technology Research and Development Program of China
WOS记录号: WOS:000345224800039
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59457
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

Recommended Citation:
Niu, Li Xuan,Feng, Zhien,Li, Jian Nan,et al. Prognostic Factors of Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Study of 168 Cases in North China[J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2014,72(11):2344-2350.
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