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学科主题: 药学
题名:
PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors
作者: He, Hai1,2; Li, Yan1,2; Jia, Xin-Ru1,2; Du, Ju3,4; Ying, Xue3,4; Lu, Wan-Liang3,4; Lou, Jin-Ning5; Wei, Yan6
关键词: Blood-brain barrier ; PAMAM dendrimer ; Dual targeting ; Drug delivery ; Brain cancer
刊名: BIOMATERIALS
发表日期: 2011
DOI: 10.1016/j.biomaterials.2010.09.002
卷: 32, 期:2, 页:478-487
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: WHEAT-GERM-AGGLUTININ ; MICROVESSEL ENDOTHELIAL-CELLS ; DRUG-DELIVERY ; IN-VITRO ; PLGA NANOPARTICLES ; BARRIER ; TRANSPORT ; TRANSFERRIN ; LIPOSOMES ; RECEPTOR
英文摘要:

A dual-targeting drug carrier (PAMAM-PEG-WGA-Tf) based on the PEGylated fourth generation (G = 4 0) PAMAM dendrimer with transferrin (Tf) and wheat germ agglutinin (WGA) on the periphery and doxorubicin (DOX) loaded in the interior was synthesized and its BBB penetration and tumor targeting properties were explored DLS and TEM measurements revealed the size of PAMAM-PEG-WGA-Tf was in the range of 14-20 nm It reduced the cytotoxicity of DOX to the normal cells greatly while efficiently inhibited the growth rate of the C6 glioma cells The assay of transport across the BBB showed that PAMAM-PEG-WGA-Tf delivered 13 5% of DOX in a period of 2 h demonstrating an enhanced transport ratio as compared to the ratio of 8% for PAMAM-PEG-WGA 7% for PAMAM-PEG-Tf and 5% for free DOX in the same period of time The accumulation of DOX in the tumor site was increased due to the targeting effects of both Tf and WGA leading to the complete breakage of the avascular C6 glioma spheroids in vitro (C) 2010 Elsevier Ltd All rights reserved

语种: 英语
所属项目编号: 2007CB935800-2007CB935801 ; NSFC 20974004
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000285401500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59463
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Key Lab Polymer Chem & Phys, Beijing 100871, Peoples R China
4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, Beijing 100871, Peoples R China
6.Minist Hlth, China Japan Friendship Hosp, Inst Clin Med Sci, Beijing, Peoples R China

Recommended Citation:
He, Hai,Li, Yan,Jia, Xin-Ru,et al. PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors[J]. BIOMATERIALS,2011,32(2):478-487.
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