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学科主题: 临床医学
题名:
Baseline Health-Related Quality of Life and 10-Year All-Cause Mortality among 1739 Chinese Adults
作者: Xie, Gaoqiang1; Laskowitz, Daniel T.2; Turner, Elizabeth L.3,4; Egger, Joseph R.4; Shi, Ping5; Ren, Fuxiu5; Gao, Wei6,7; Wu, Yangfeng1,8,9
刊名: PLOS ONE
发表日期: 2014-07-09
DOI: 10.1371/journal.pone.0101527
卷: 9, 期:7
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: PREDICTS MORTALITY ; POPULATION ; DISEASE ; RISK
英文摘要:

Background and Purpose: Health-related quality of life (HRQOL) may be associated with the longevity of patients; yet it is not clear whether this association holds in a general population, especially in low- and middle-income countries. The objective of this study was to determine whether baseline HRQOL was associated with 10-year all-cause mortality in a Chinese general population.

Methods: A prospective cohort study was conducted from 2002 to 2012 on 1739 participants in 11 villages of Beijing. Baseline data on six domains of HRQOL, chronic diseases and cardiovascular risk factors were collected in either 2002 (n = 1290) or 2005 (n = 449). Subjects were followed through the end of the study period, or until they were censored due to death or loss to follow-up, whichever came first.

Results: A multivariable Cox model estimated that Total HRQOL score (bottom 50% versus top 50%) was associated with a 44% increase in all-cause mortality (Hazard Ratio [HR] = 1.44; 95% confidence interval [CI]: 1.00-2.06), after adjusting for sex, age, education levels, occupation, marital status, smoking status, fruit intake, vegetable intake, physical exercise, hypertension, history of a stroke, myocardial infarction, chronic respiratory disease, and kidney disease. Among the six HRQOL domains, the Independence domain had the largest fully adjusted HR (HR = 1.66; 95% CI: 1.13-2.42), followed by Psychological (HR = 1.47; 95% CI: 1.03-2.09), Environmental (HR = 1.43, 95% CI: 1.003-2.03), Physical (HR = 1.38; 95% CI: 0.97-1.95), General (HR = 1.37; 95% CI: 0.97-1.94), and the Social domain (HR = 1.15; 95% CI: 0.81-1.65).

Conclusion: Lower HRQOL, especially the inability to live independently, was associated with a significantly increased risk of 10-year all-cause mortality. The inclusion of HRQOL measures in clinical assessment may improve diagnostic accuracy to improve clinical outcomes and better target public health promotions.

语种: 英语
所属项目编号: 2001BA703B01 ; 30471494 ; 30872168 ; P-1-00242 ; 1D43-TW008308-01
项目资助者: People&prime ; s Republic of China National 10th Five-Year Plan Science and Technology Key Projects ; National Natural Science Foundation of China ; Duke University, Medical Center, and Health System ; National Institutes of Health, USA
WOS记录号: WOS:000339040600042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59465
Appears in Collections:北京大学临床研究所_期刊论文

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作者单位: 1.Shijingshan Ctr Dis Control & Prevent, Beijing, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.Duke Univ, Duke Global Hlth Inst, Durham, NC USA
4.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
5.Duke Univ, Med Ctr, Dept Neurol, Durham, NC USA
6.Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA
7.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
8.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
9.Peking Univ, Hlth Sci Ctr, George Inst Global Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Xie, Gaoqiang,Laskowitz, Daniel T.,Turner, Elizabeth L.,et al. Baseline Health-Related Quality of Life and 10-Year All-Cause Mortality among 1739 Chinese Adults[J]. PLOS ONE,2014,9(7).
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