IR@PKUHSC  > 北京大学临床研究所
学科主题临床医学
Baseline Health-Related Quality of Life and 10-Year All-Cause Mortality among 1739 Chinese Adults
Xie, Gaoqiang1; Laskowitz, Daniel T.2; Turner, Elizabeth L.3,4; Egger, Joseph R.4; Shi, Ping5; Ren, Fuxiu5; Gao, Wei6,7; Wu, Yangfeng1,8,9
刊名PLOS ONE
2014-07-09
DOI10.1371/journal.pone.0101527
9期:7
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]PREDICTS MORTALITY ; POPULATION ; DISEASE ; RISK
英文摘要

Background and Purpose: Health-related quality of life (HRQOL) may be associated with the longevity of patients; yet it is not clear whether this association holds in a general population, especially in low- and middle-income countries. The objective of this study was to determine whether baseline HRQOL was associated with 10-year all-cause mortality in a Chinese general population.

Methods: A prospective cohort study was conducted from 2002 to 2012 on 1739 participants in 11 villages of Beijing. Baseline data on six domains of HRQOL, chronic diseases and cardiovascular risk factors were collected in either 2002 (n = 1290) or 2005 (n = 449). Subjects were followed through the end of the study period, or until they were censored due to death or loss to follow-up, whichever came first.

Results: A multivariable Cox model estimated that Total HRQOL score (bottom 50% versus top 50%) was associated with a 44% increase in all-cause mortality (Hazard Ratio [HR] = 1.44; 95% confidence interval [CI]: 1.00-2.06), after adjusting for sex, age, education levels, occupation, marital status, smoking status, fruit intake, vegetable intake, physical exercise, hypertension, history of a stroke, myocardial infarction, chronic respiratory disease, and kidney disease. Among the six HRQOL domains, the Independence domain had the largest fully adjusted HR (HR = 1.66; 95% CI: 1.13-2.42), followed by Psychological (HR = 1.47; 95% CI: 1.03-2.09), Environmental (HR = 1.43, 95% CI: 1.003-2.03), Physical (HR = 1.38; 95% CI: 0.97-1.95), General (HR = 1.37; 95% CI: 0.97-1.94), and the Social domain (HR = 1.15; 95% CI: 0.81-1.65).

Conclusion: Lower HRQOL, especially the inability to live independently, was associated with a significantly increased risk of 10-year all-cause mortality. The inclusion of HRQOL measures in clinical assessment may improve diagnostic accuracy to improve clinical outcomes and better target public health promotions.

语种英语
WOS记录号WOS:000339040600042
项目编号2001BA703B01 ; 30471494 ; 30872168 ; P-1-00242 ; 1D43-TW008308-01
资助机构People&prime ; s Republic of China National 10th Five-Year Plan Science and Technology Key Projects ; National Natural Science Foundation of China ; Duke University, Medical Center, and Health System ; National Institutes of Health, USA
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59465
专题北京大学临床研究所
北京大学第三临床医学院_心血管内科
作者单位1.Shijingshan Ctr Dis Control & Prevent, Beijing, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.Duke Univ, Duke Global Hlth Inst, Durham, NC USA
4.Peking Univ, Clin Res Inst, Beijing 100871, Peoples R China
5.Duke Univ, Med Ctr, Dept Neurol, Durham, NC USA
6.Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA
7.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
8.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
9.Peking Univ, Hlth Sci Ctr, George Inst Global Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xie, Gaoqiang,Laskowitz, Daniel T.,Turner, Elizabeth L.,et al. Baseline Health-Related Quality of Life and 10-Year All-Cause Mortality among 1739 Chinese Adults[J]. PLOS ONE,2014,9(7).
APA Xie, Gaoqiang.,Laskowitz, Daniel T..,Turner, Elizabeth L..,Egger, Joseph R..,Shi, Ping.,...&Wu, Yangfeng.(2014).Baseline Health-Related Quality of Life and 10-Year All-Cause Mortality among 1739 Chinese Adults.PLOS ONE,9(7).
MLA Xie, Gaoqiang,et al."Baseline Health-Related Quality of Life and 10-Year All-Cause Mortality among 1739 Chinese Adults".PLOS ONE 9.7(2014).
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