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学科主题: 临床医学
题名:
Association of polymorphisms of interleukin-18 gene promoter region with polycystic ovary syndrome in chinese population
作者: Yang, Yan; Qiao, Jie; Li, Mei-Zhi
刊名: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
发表日期: 2010-10-22
DOI: 10.1186/1477-7827-8-125
卷: 8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]: Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]: SINGLE-NUCLEOTIDE POLYMORPHISMS ; RHEUMATOID-ARTHRITIS PATIENTS ; HOMEOSTASIS MODEL ASSESSMENT ; TYPE-2 DIABETES-MELLITUS ; INSULIN-RESISTANCE ; IL-18 GENE ; IL18 GENE ; WOMEN ; PREVALENCE ; DISEASE
英文摘要:

Background: Recent research shows that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, and that PCOS may induce an increase in serum interleukin-18 (IL-18) levels.

Methods: To investigate the polymorphisms of the IL-18 gene promoters with PCOS, two single nucleotide polymorphisms (SNPs) in the promoter of the IL-18 gene (at positions -607C/A and -137G/C) in 118 Chinese women with PCOS and 79 controls were evaluated using polymerase chain reaction (PCR).

Results: No significant differences were found in the genotype distribution, allele frequency and haplotype frequency between the PCOS and control groups. Further analysis demonstrated a relationship between IL-18 gene promoter polymorphisms and PCOS insulin resistance (IR). Regarding the -137 allele frequency, G and C allele frequencies were 93.5% and 6.5%, respectively, in the PCOS with IR patients; G and C allele frequencies were 85.4% and 14.6%, respectively, in PCOS patients without IR (chi2 = 3.601, P = 0.048).

Conclusions: The presence of a polymorphism in the IL-18 gene was found to have no correlation with the occurrence of PCOS. Carriage of the C allele at position -137 in the promoter of the IL-18 gene may play a protective role from the development of PCOS IR.

语种: 英语
所属项目编号: 2007BA104B00
项目资助者: National Key Technology RD Program
WOS记录号: WOS:000283935800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59472
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Yan,Qiao, Jie,Li, Mei-Zhi. Association of polymorphisms of interleukin-18 gene promoter region with polycystic ovary syndrome in chinese population[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2010,8.
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