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学科主题: 临床医学
题名:
Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis
作者: Seyedmousavi, S.1,2; Samerpitak, K.3,4,5; Rijs, A. J. M. M.1; Melchers, W. J. G.1; Mouton, J. W.1; Verweij, P. E.1; de Hoog, G. S.4,5,6,7,8,9,10
刊名: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
发表日期: 2014-06-01
DOI: 10.1128/AAC.00002-14
卷: 58, 期:6, 页:3285-3292
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: OF-THE-LITERATURE ; DACTYLARIA-GALLOPAVA ; DISSEMINATED PHEOHYPHOMYCOSIS ; CEREBRAL PHEOHYPHOMYCOSIS ; TRANSPLANT PATIENT ; MURINE MODEL ; CELL TYPE ; POSACONAZOLE ; INFECTION ; ENCEPHALITIS
英文摘要:

Species of Verruconis and species of Ochroconis are dematiaceous fungi generally found in the environment but having the ability to infect humans, dogs, cats, poultry, and fish. This study presents the antifungal susceptibility patterns of these fungi at the species level. Forty strains originating from clinical and environmental sources were phylogenetically identified at the species level by using sequences of the ribosomal DNA internal transcribed spacer (rDNA ITS). In vitro antifungal susceptibility testing was performed against eight antifungals, using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. The geometric mean MICs for amphotericin B (AMB), flucytosine (5FC), fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), and posaconazole (POS) and minimum effective concentrations (MECs) for caspofungin (CAS) and anidulafungin (AFG) across the Ochroconis and Verruconis species were as follows, in increasing order. For Verruconis species, the values (mu g/ml) were as follows: AFG, 0.04; POS, 0.25; ITC, 0.37; AMB, 0.50; CAS, 0.65; VRC, 0.96; 5FC, 10.45; and FLC, 47.25. For Ochroconis species, the values (mu g/ml) were as follows: AFG, 0.06; POS, 0.11; CAS, 0.67; VRC, 2.76; ITC, 3.94; AMB, 5.68; 5FC, 34.48; and FLC, 61.33. Antifungal susceptibility of Ochroconis and Verruconis was linked with phylogenetic distance and thermotolerance. Echinocandins and POS showed the greatest in vitro activity, providing possible treatment options for Ochroconis and Verruconis infections.

语种: 英语
项目资助者: Astellas ; Basilea ; Gilead Sciences ; Merck ; Pfizer
WOS记录号: WOS:000338776900037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59482
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.King Abdullassiz Univ, Jeddah, Saudi Arabia
2.Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands
3.Mazandaran Univ Med Sci, Invas Fungi Res Ctr, Sari, Iran
4.Khon Kaen Univ, Fac Med, Dept Microbiol, Khon Kaen, Thailand
5.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
6.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
7.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
10.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil

Recommended Citation:
Seyedmousavi, S.,Samerpitak, K.,Rijs, A. J. M. M.,et al. Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2014,58(6):3285-3292.
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