IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis
Seyedmousavi, S.1,2; Samerpitak, K.3,4,5; Rijs, A. J. M. M.1; Melchers, W. J. G.1; Mouton, J. W.1; Verweij, P. E.1; de Hoog, G. S.4,5,6,7,8,9,10
刊名ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2014-06-01
DOI10.1128/AAC.00002-14
58期:6页:3285-3292
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Microbiology ; Pharmacology & Pharmacy
关键词[WOS]OF-THE-LITERATURE ; DACTYLARIA-GALLOPAVA ; DISSEMINATED PHEOHYPHOMYCOSIS ; CEREBRAL PHEOHYPHOMYCOSIS ; TRANSPLANT PATIENT ; MURINE MODEL ; CELL TYPE ; POSACONAZOLE ; INFECTION ; ENCEPHALITIS
英文摘要

Species of Verruconis and species of Ochroconis are dematiaceous fungi generally found in the environment but having the ability to infect humans, dogs, cats, poultry, and fish. This study presents the antifungal susceptibility patterns of these fungi at the species level. Forty strains originating from clinical and environmental sources were phylogenetically identified at the species level by using sequences of the ribosomal DNA internal transcribed spacer (rDNA ITS). In vitro antifungal susceptibility testing was performed against eight antifungals, using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. The geometric mean MICs for amphotericin B (AMB), flucytosine (5FC), fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), and posaconazole (POS) and minimum effective concentrations (MECs) for caspofungin (CAS) and anidulafungin (AFG) across the Ochroconis and Verruconis species were as follows, in increasing order. For Verruconis species, the values (mu g/ml) were as follows: AFG, 0.04; POS, 0.25; ITC, 0.37; AMB, 0.50; CAS, 0.65; VRC, 0.96; 5FC, 10.45; and FLC, 47.25. For Ochroconis species, the values (mu g/ml) were as follows: AFG, 0.06; POS, 0.11; CAS, 0.67; VRC, 2.76; ITC, 3.94; AMB, 5.68; 5FC, 34.48; and FLC, 61.33. Antifungal susceptibility of Ochroconis and Verruconis was linked with phylogenetic distance and thermotolerance. Echinocandins and POS showed the greatest in vitro activity, providing possible treatment options for Ochroconis and Verruconis infections.

语种英语
WOS记录号WOS:000338776900037
资助机构Astellas ; Basilea ; Gilead Sciences ; Merck ; Pfizer
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59482
专题北京大学第一临床医学院_皮肤性病科
作者单位1.King Abdullassiz Univ, Jeddah, Saudi Arabia
2.Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands
3.Mazandaran Univ Med Sci, Invas Fungi Res Ctr, Sari, Iran
4.Khon Kaen Univ, Fac Med, Dept Microbiol, Khon Kaen, Thailand
5.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
6.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
7.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
10.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil
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GB/T 7714
Seyedmousavi, S.,Samerpitak, K.,Rijs, A. J. M. M.,et al. Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2014,58(6):3285-3292.
APA Seyedmousavi, S..,Samerpitak, K..,Rijs, A. J. M. M..,Melchers, W. J. G..,Mouton, J. W..,...&de Hoog, G. S..(2014).Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,58(6),3285-3292.
MLA Seyedmousavi, S.,et al."Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 58.6(2014):3285-3292.
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