IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival
Li, Hongxia; Yao, Lihua; Tao Ouyang; Li, Jinfeng; Wang, Tianfeng; Fan, Zhaoqing; Fan, Tie; Dong, Bin; Lin, Benyao; Li, Jiyou; Xie, Yuntao
刊名CARCINOGENESIS
2007-02-01
DOI10.1093/carcin/bgl153
28期:2页:372-377
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]LUNG-CANCER ; P53 ARG72PRO ; RANDOMIZED-TRIALS ; CELL CARCINOMA ; RISK ; GENE ; EXPRESSION ; DELTA-NP73 ; EXON-2 ; ALLELE
英文摘要

p73 gene shares structural and functional similarities to p53, and plays an important role in modulating cell-cycle arrest and apoptosis. A common non-coding polymorphism of exon 2 of the p73 gene (designated as GC/AT) may affect gene expression, thus, it may lead to functional significance. The correlation of this polymorphism with breast cancer survival has not been investigated. In this study, by using genomic DNA p73 GC/AT polymorphism was detected by PCR-SSCP in 526 breast cancer patients with a median follow-up of 7.3 years. Among the 526 breast cancer patients, 4% of the patients were homozygous for the AT/AT genotype, 39% were heterozygous GC/AT and 57% were homozygous for the GC/GC genotype. We found that patients with the GC/GC genotype had a significantly worse clinical outcome than did patients with the AT Variants (AT/AT or GC/AT genotype) (5-year disease-free survival, 74.2 versus 95.0 or 84.1%, P = 0.02; 5-year overall survival, 78.9 versus 95.0 or 87.5%, P = 0.01, respectively). As compared with the GC/AT and AT/AT genotypes, the GC/GC genotype remained an independent prognostic indicator of disease-free survival (HR 1.82, P = 0.003) and overall survival (HR 1.99, P = 0.004) in multivariate analysis. Our results suggest that the GC/GC genotype is significantly associated with poor prognosis in breast cancer and raise the possibility that analysis of p73 polymorphism may provide useful prognostic information for breast cancer patients. Additional independent studies are needed to confirm these findings.

语种英语
WOS记录号WOS:000244124800016
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59483
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Breast Ctr, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
推荐引用方式
GB/T 7714
Li, Hongxia,Yao, Lihua,Tao Ouyang,et al. Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival[J]. CARCINOGENESIS,2007,28(2):372-377.
APA Li, Hongxia.,Yao, Lihua.,Tao Ouyang.,Li, Jinfeng.,Wang, Tianfeng.,...&Xie, Yuntao.(2007).Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival.CARCINOGENESIS,28(2),372-377.
MLA Li, Hongxia,et al."Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival".CARCINOGENESIS 28.2(2007):372-377.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Hongxia]的文章
[Yao, Lihua]的文章
[Tao Ouyang]的文章
百度学术
百度学术中相似的文章
[Li, Hongxia]的文章
[Yao, Lihua]的文章
[Tao Ouyang]的文章
必应学术
必应学术中相似的文章
[Li, Hongxia]的文章
[Yao, Lihua]的文章
[Tao Ouyang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。