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Fragmentation patterns of novel dispirocyclopiperazinum dibromides with strong analgesic activity under electroscopy ionization tandem mass sprectroscopy conditions
Wang, X; Sha, YW; Li, RT
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2004
DOI10.1002/rcm.1407
18期:8页:829-833
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Spectroscopy
研究领域[WOS]Chemistry ; Spectroscopy
关键词[WOS]UNIQUE SPIROCYCLOPIPERAZINIUM SALT ; QUATERNARY AMMONIUM HERBICIDES ; BIOLOGICAL-ACTIVITIES ; SPECTROMETRY ; PARAQUAT ; DIQUAT ; PESTICIDES ; WATER ; BRAIN
英文摘要

The fragmentation patterns of a series of dispiracyclopiperazinium dibromides with strong analgesic activity by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry (ESI-MSn). Instead of the parent molecular ions, the fragment ions [M-Br](+) are detected as characteristics double peaks and usually the base peaks. Meanwhile, the fragment ions [M-2Br](2+) are unique for this series of diquaternary ammonium dibromides and show high intensity. Besides the common fragmentation patterns around the carbonyl group, elimination of hydrogen bromide from [M-Br](+) ions is anothe important pathway. Following the elimination, an interesting rearrangement takes place in the unsturated spirocyclopiperazine and transforms it into a dihydropyrrole structure, whose fragmentations are similar to its precursor ion in the succeeding steps. Copyright (C) 2004 John Whiley Sons, Ltd.

语种英语
WOS记录号WOS:000220963900001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59485
专题北京大学药学院
作者单位1.Tsing Hua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem, Minist Educ, Beijing 100084, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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Wang, X,Sha, YW,Li, RT. Fragmentation patterns of novel dispirocyclopiperazinum dibromides with strong analgesic activity under electroscopy ionization tandem mass sprectroscopy conditions[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2004,18(8):829-833.
APA Wang, X,Sha, YW,&Li, RT.(2004).Fragmentation patterns of novel dispirocyclopiperazinum dibromides with strong analgesic activity under electroscopy ionization tandem mass sprectroscopy conditions.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,18(8),829-833.
MLA Wang, X,et al."Fragmentation patterns of novel dispirocyclopiperazinum dibromides with strong analgesic activity under electroscopy ionization tandem mass sprectroscopy conditions".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 18.8(2004):829-833.
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