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学科主题: 药学
题名:
Fragmentation patterns of novel dispirocyclopiperazinum dibromides with strong analgesic activity under electroscopy ionization tandem mass sprectroscopy conditions
作者: Wang, X; Sha, YW; Li, RT
刊名: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
发表日期: 2004
DOI: 10.1002/rcm.1407
卷: 18, 期:8, 页:829-833
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Spectroscopy
研究领域[WOS]: Chemistry ; Spectroscopy
关键词[WOS]: UNIQUE SPIROCYCLOPIPERAZINIUM SALT ; QUATERNARY AMMONIUM HERBICIDES ; BIOLOGICAL-ACTIVITIES ; SPECTROMETRY ; PARAQUAT ; DIQUAT ; PESTICIDES ; WATER ; BRAIN
英文摘要:

The fragmentation patterns of a series of dispiracyclopiperazinium dibromides with strong analgesic activity by positive ion electrospray ionization mass spectrometry in conjunction with tandem mass spectrometry (ESI-MSn). Instead of the parent molecular ions, the fragment ions [M-Br](+) are detected as characteristics double peaks and usually the base peaks. Meanwhile, the fragment ions [M-2Br](2+) are unique for this series of diquaternary ammonium dibromides and show high intensity. Besides the common fragmentation patterns around the carbonyl group, elimination of hydrogen bromide from [M-Br](+) ions is anothe important pathway. Following the elimination, an interesting rearrangement takes place in the unsturated spirocyclopiperazine and transforms it into a dihydropyrrole structure, whose fragmentations are similar to its precursor ion in the succeeding steps. Copyright (C) 2004 John Whiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000220963900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59485
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Tsing Hua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem, Minist Educ, Beijing 100084, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, X,Sha, YW,Li, RT. Fragmentation patterns of novel dispirocyclopiperazinum dibromides with strong analgesic activity under electroscopy ionization tandem mass sprectroscopy conditions[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2004,18(8):829-833.
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