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学科主题: 公共卫生
题名:
Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials
作者: Ma, De-Fu1,2; Qin, Li-Qiang3; Wang, Pei-Yu1; Katoh, Ryohei2
关键词: isoflavone ; osteoporosis ; bone mineral density ; bone mineral content
刊名: CLINICAL NUTRITION
发表日期: 2008-02-01
DOI: 10.1016/j.clnu.2007.10.012
卷: 27, 期:1, 页:57-64
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: POSTMENOPAUSAL WOMEN ; PREMENOPAUSAL WOMEN ; PHYTO-ESTROGENS ; JAPANESE WOMEN ; PROTEIN ; HEALTH ; METABOLISM ; PHYTOESTROGENS ; OSTEOPOROSIS ; CONSUMPTION
英文摘要:

Background & aims: The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss.

Methods: We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software.

Results: Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm(2) (95% confidence interval: 4.5-36.6 mg/cm(2)) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral, content by 0.93g (95% confidence interval: -0.37 to 2.24g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5 mg/cm(2) (95% confidence interval: 8.4-48.6 mg/cm(2)) and 27 mg/cm(2) (95% confidence interval: 8.3-45.8 mg/cm(2)), respectively.

Conclusions: Isoflavone intervention significantly attenuates bone toss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. (C) 2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

语种: 英语
WOS记录号: WOS:000254373200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59502
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Univ Yamanashi, Dept Human Pathol, Interdisciplinary Grad Sch Med & Engn, Yamanashi 4093898, Japan
3.Soochow Univ, Dept Nutr & Food Hyg, Sch Radiat Med & Publ Hlth, Suzhou 215123, Peoples R China

Recommended Citation:
Ma, De-Fu,Qin, Li-Qiang,Wang, Pei-Yu,et al. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials[J]. CLINICAL NUTRITION,2008,27(1):57-64.
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