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Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials
Ma, De-Fu1,2; Qin, Li-Qiang3; Wang, Pei-Yu1; Katoh, Ryohei2
关键词isoflavone osteoporosis bone mineral density bone mineral content
刊名CLINICAL NUTRITION
2008-02-01
DOI10.1016/j.clnu.2007.10.012
27期:1页:57-64
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]POSTMENOPAUSAL WOMEN ; PREMENOPAUSAL WOMEN ; PHYTO-ESTROGENS ; JAPANESE WOMEN ; PROTEIN ; HEALTH ; METABOLISM ; PHYTOESTROGENS ; OSTEOPOROSIS ; CONSUMPTION
英文摘要

Background & aims: The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss.

Methods: We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software.

Results: Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm(2) (95% confidence interval: 4.5-36.6 mg/cm(2)) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral, content by 0.93g (95% confidence interval: -0.37 to 2.24g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5 mg/cm(2) (95% confidence interval: 8.4-48.6 mg/cm(2)) and 27 mg/cm(2) (95% confidence interval: 8.3-45.8 mg/cm(2)), respectively.

Conclusions: Isoflavone intervention significantly attenuates bone toss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. (C) 2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

语种英语
WOS记录号WOS:000254373200006
引用统计
被引频次:103[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59502
专题北京大学公共卫生学院
作者单位1.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Univ Yamanashi, Dept Human Pathol, Interdisciplinary Grad Sch Med & Engn, Yamanashi 4093898, Japan
3.Soochow Univ, Dept Nutr & Food Hyg, Sch Radiat Med & Publ Hlth, Suzhou 215123, Peoples R China
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GB/T 7714
Ma, De-Fu,Qin, Li-Qiang,Wang, Pei-Yu,et al. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials[J]. CLINICAL NUTRITION,2008,27(1):57-64.
APA Ma, De-Fu,Qin, Li-Qiang,Wang, Pei-Yu,&Katoh, Ryohei.(2008).Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials.CLINICAL NUTRITION,27(1),57-64.
MLA Ma, De-Fu,et al."Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials".CLINICAL NUTRITION 27.1(2008):57-64.
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