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学科主题: 基础医学
题名:
Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns
作者: Jia, Jianwei1; Li, Yuxiang2; Lei, Zhen1; Hao, Yinju1; Wu, Yang1; Zhao, Qipeng1; Wang, Hao3; Ma, Lin4; Liu, Juan5; Zhao, Chengjun5; Jiang, Yuanxu1; Wang, Yanrong6; Tan, Hanran7; Dai, Xiuying3; Zhang, Wannian8; Sun, Tao4; Yu, Jianqiang9
关键词: Contraction ; dysmenorrhea ; spasmolytic effect
刊名: PHARMACEUTICAL BIOLOGY
发表日期: 2013-06-01
DOI: 10.3109/13880209.2013.764536
卷: 51, 期:6, 页:744-748
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
关键词[WOS]: NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; SMOOTH-MUSCLE ; GLYCYRRHIZAE-RADIX ; INHIBITION ; RISK ; ACTS
英文摘要:

Context: Primary dysmenorrhea is one of the most frequent gynecological disorders in young women. Chinese herbal medicine has the advantage in terms of multi-targeting efficacy, lower toxicity, as well as lower cost. Core licorice is the hard and atropurpureus heart part in root and rootstock of Glycyrrhiza uralensis Fisch (Leguminosae), having a therapeutic effect on dysmenorrhea.

Objective: This experiment indicated the spasmolytic effect of core licorice aqueous extract (CLE) on spontaneous rhythmic contractions and spasmogen-provoked contractions of stilbestrol primed, estrogen-dominated, non-pregnant mouse isolated uterine horns and its spasmolytic mechanism.

Materials and methods: We investigated the spasmolytic effect of CLE (0.025-0.1 mg/mL) on spontaneous contractions and potassium chloride (KCl, 40 mM), acetylcholine (ACh, 5 mu g/mL), carbachol (CCh, 5 mu g/mL), oxytocin (OT, 2 U/L) or bradykinin (5 ng/mL)-provoked contractions of mouse isolated uterine horns. Contractions were recorded by tension force transducers using Biolap 420F software on a PC.

Results: Our present study showed that graded, escalated concentrations of CLE (0.025-0.1 mg/mL) significantly inhibited the amplitude of spontaneous phasic contractions (15.03-55.10%), as well as the contractions produced by KCl (40 mM; 20.16-53.99%), ACh (5 mu g/mL; 14.65-48.32%), CCh (5 mu g/mL; 38.40-76.70%), OT (2 U/L; 21.53-58.49%) or bradykinin (5 ng/mL; 58.01-79.44%) of the estrogen-dominated isolated mice uterine horn preparations in a concentration-related manner.

Discussion and conclusion: The spasmolytic effect of CLE observed in the present study lends pharmacological support to the traditional use of core licorice in the management, control and treatment of primary dysmenorrhea.

语种: 英语
所属项目编号: 309605060 ; NZ11212
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of NingXia
WOS记录号: WOS:000318941100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59503
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Ningxia Med Univ, Coll Pharm, Yinchuan, Peoples R China
2.Key Lab Fertil Preservat & Maintenance, Yinchuan, Peoples R China
3.Ningxia Hui Med Modern Engn Res Ctr, Yinchuan, Peoples R China
4.Ningxia Med Univ, Dept Pharmacol, Yinchuan, Peoples R China
5.Ningxia Med Univ, Coll Nursing, Yinchuan, Peoples R China
6.Ningxia Key Lab Craniocerbral Dis Ningxia Hui Aut, Yinchuan, Peoples R China
7.Ningxia Med Univ, Sch Basis Med Sci, Yinchuan, Peoples R China
8.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100871, Peoples R China
9.Ningxia Med Univ, Med Sci Tech Res Ctr, Yinchuan 750004, Ningxia, Peoples R China

Recommended Citation:
Jia, Jianwei,Li, Yuxiang,Lei, Zhen,et al. Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns[J]. PHARMACEUTICAL BIOLOGY,2013,51(6):744-748.
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