IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns
Jia, Jianwei1; Li, Yuxiang2; Lei, Zhen1; Hao, Yinju1; Wu, Yang1; Zhao, Qipeng1; Wang, Hao3; Ma, Lin4; Liu, Juan5; Zhao, Chengjun5; Jiang, Yuanxu1; Wang, Yanrong6; Tan, Hanran7; Dai, Xiuying3; Zhang, Wannian8; Sun, Tao4; Yu, Jianqiang9
关键词Contraction dysmenorrhea spasmolytic effect
刊名PHARMACEUTICAL BIOLOGY
2013-06-01
DOI10.3109/13880209.2013.764536
51期:6页:744-748
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
关键词[WOS]NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; SMOOTH-MUSCLE ; GLYCYRRHIZAE-RADIX ; INHIBITION ; RISK ; ACTS
英文摘要

Context: Primary dysmenorrhea is one of the most frequent gynecological disorders in young women. Chinese herbal medicine has the advantage in terms of multi-targeting efficacy, lower toxicity, as well as lower cost. Core licorice is the hard and atropurpureus heart part in root and rootstock of Glycyrrhiza uralensis Fisch (Leguminosae), having a therapeutic effect on dysmenorrhea.

Objective: This experiment indicated the spasmolytic effect of core licorice aqueous extract (CLE) on spontaneous rhythmic contractions and spasmogen-provoked contractions of stilbestrol primed, estrogen-dominated, non-pregnant mouse isolated uterine horns and its spasmolytic mechanism.

Materials and methods: We investigated the spasmolytic effect of CLE (0.025-0.1 mg/mL) on spontaneous contractions and potassium chloride (KCl, 40 mM), acetylcholine (ACh, 5 mu g/mL), carbachol (CCh, 5 mu g/mL), oxytocin (OT, 2 U/L) or bradykinin (5 ng/mL)-provoked contractions of mouse isolated uterine horns. Contractions were recorded by tension force transducers using Biolap 420F software on a PC.

Results: Our present study showed that graded, escalated concentrations of CLE (0.025-0.1 mg/mL) significantly inhibited the amplitude of spontaneous phasic contractions (15.03-55.10%), as well as the contractions produced by KCl (40 mM; 20.16-53.99%), ACh (5 mu g/mL; 14.65-48.32%), CCh (5 mu g/mL; 38.40-76.70%), OT (2 U/L; 21.53-58.49%) or bradykinin (5 ng/mL; 58.01-79.44%) of the estrogen-dominated isolated mice uterine horn preparations in a concentration-related manner.

Discussion and conclusion: The spasmolytic effect of CLE observed in the present study lends pharmacological support to the traditional use of core licorice in the management, control and treatment of primary dysmenorrhea.

语种英语
WOS记录号WOS:000318941100010
项目编号309605060 ; NZ11212
资助机构National Natural Science Foundation of China ; Natural Science Foundation of NingXia
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59503
专题北京大学基础医学院_药理学系
作者单位1.Ningxia Med Univ, Coll Pharm, Yinchuan, Peoples R China
2.Key Lab Fertil Preservat & Maintenance, Yinchuan, Peoples R China
3.Ningxia Hui Med Modern Engn Res Ctr, Yinchuan, Peoples R China
4.Ningxia Med Univ, Dept Pharmacol, Yinchuan, Peoples R China
5.Ningxia Med Univ, Coll Nursing, Yinchuan, Peoples R China
6.Ningxia Key Lab Craniocerbral Dis Ningxia Hui Aut, Yinchuan, Peoples R China
7.Ningxia Med Univ, Sch Basis Med Sci, Yinchuan, Peoples R China
8.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100871, Peoples R China
9.Ningxia Med Univ, Med Sci Tech Res Ctr, Yinchuan 750004, Ningxia, Peoples R China
推荐引用方式
GB/T 7714
Jia, Jianwei,Li, Yuxiang,Lei, Zhen,et al. Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns[J]. PHARMACEUTICAL BIOLOGY,2013,51(6):744-748.
APA Jia, Jianwei.,Li, Yuxiang.,Lei, Zhen.,Hao, Yinju.,Wu, Yang.,...&Yu, Jianqiang.(2013).Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns.PHARMACEUTICAL BIOLOGY,51(6),744-748.
MLA Jia, Jianwei,et al."Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns".PHARMACEUTICAL BIOLOGY 51.6(2013):744-748.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Relaxative effect of(554KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jia, Jianwei]的文章
[Li, Yuxiang]的文章
[Lei, Zhen]的文章
百度学术
百度学术中相似的文章
[Jia, Jianwei]的文章
[Li, Yuxiang]的文章
[Lei, Zhen]的文章
必应学术
必应学术中相似的文章
[Jia, Jianwei]的文章
[Li, Yuxiang]的文章
[Lei, Zhen]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Relaxative effect of core licorice aqueous extract on mouse isolated uterine horns.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。