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CFB/C2 Gene Polymorphisms and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
Sun, Chuan1; Zhao, Min1; Li, Xiaoxin1
关键词CFB/C2 gene Polymorphisms Age-related macular degeneration Systematic review Meta-analysis
刊名CURRENT EYE RESEARCH
2012-04-01
DOI10.3109/02713683.2011.635401
37期:4页:259-271
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]COMPLEMENT-FACTOR-H ; GENOME-WIDE ASSOCIATION ; HARDY-WEINBERG EQUILIBRIUM ; COMPONENT 2 C2 ; FACTOR-B BF ; EYE DISEASE ; CHINESE POPULATION ; CUMULATIVE METAANALYSIS ; INCREASES RISK ; EXACT TESTS
英文摘要

Purpose: To investigate whether the polymorphisms of CFB/C2 gene are associated with age-related macular degeneration (AMD), and to evaluate the magnitude of gene effect.

Methods: We performed a meta-analysis of the association between four SNPs in CFB/C2 gene (rs9332739, rs547154, rs4151667, and rs641153) and risk of AMD using data from 15 case-control studies involving 8905 subjects. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed-and random-effects models. The Q and I-2 statistics were used to evaluate between-study heterogeneity. Harbord′s modified test was used to detect small study effects. Sensitivity analysis, cumulative meta-analysis, and meta-regression were also performed.

Results: For rs9332739, rs547154, rs4151667, and rs641153, the pooled ORs in a dominant genetic model were 0.474 (fixed effects, P < 0.001, 95% CI 0.378-0.596), 0.399 (random effects, 95% CI 0.289-0.551, P < 0.001), 0.496 (fixed effects, 95% CI 0.390-0.632, P < 0.001), and 0.557 (random effects, P = 0.008, 95% CI 0.362-0.856), respectively. These results suggested that variant alleles of all the four SNPs has significant protective effect against AMD. Contour-enhanced funnel plots and Harbord′s test showed moderate small study effects for rs9332739 and rs4151667. Heterogeneity were found for rs547154 and rs641153, subgroup analysis suggested that ethnicity was the main source for heterogeneity. Stratification by ethnicity indicated stronger protective effects of rare alleles in Caucasians. Genotype distribution analysis also suggested that frequencies of rare homozygous genotype were higher in Caucasian group.

Conclusions: Our meta-analysis indicated strong protective effects of the variant alleles of four SNPs in CFB/C2 gene (rs9332739, rs547154, rs4151667, and rs641153) against AMD. The disease risk descended to nearly one half for individuals carrying at least one copy of the rare alleles. The protective effects seemed to be stronger in Caucasians, of which the genotype frequencies were also higher.

语种英语
WOS记录号WOS:000302052700001
项目编号2011 CB 510200
资助机构National Basic Research Program of China (973 program)
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59504
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Sun, Chuan,Zhao, Min,Li, Xiaoxin. CFB/C2 Gene Polymorphisms and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis[J]. CURRENT EYE RESEARCH,2012,37(4):259-271.
APA Sun, Chuan,Zhao, Min,&Li, Xiaoxin.(2012).CFB/C2 Gene Polymorphisms and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.CURRENT EYE RESEARCH,37(4),259-271.
MLA Sun, Chuan,et al."CFB/C2 Gene Polymorphisms and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis".CURRENT EYE RESEARCH 37.4(2012):259-271.
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