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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Effect of homocysteine on plaque formation and oxidative stress in patients with acute coronary syndromes
作者: Wang, G; Mao, JM; Wang, X; Zhang, FC
关键词: homocysteine ; arteriosclerosis ; cytokines
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2004-11-01
卷: 117, 期:11, 页:1650-1654
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: EXTRACELLULAR-SUPEROXIDE DISMUTASE ; ARTERY-DISEASE ; IN-VITRO ; PROLIFERATION ; EXPRESSION ; MECHANISM
英文摘要:

Background Cardiovascular diseases, especially coronary artery disease (CAD), are major causes of death in industrialized countries. Elevated concentrations of plasma homocysteine (Hcy) have been associated with an increased risk of CAD.. Increased plasma levels of chemokine, characterized by their ability to induce migration and activation of leukocytes, may contribute to the pathogenesis of CAD. This study was designed to investigate the changes of plasma Hcy, monocyte chemoattractant protein-1 (MCP-1) and oxidative stress markers in acute coronary syndrome patients.

Methods A total of 149 subjects were divided into four groups: 50 patients with unstable angina, 30 patients with acute myocardial infarction, 20 coronary restenosis patients after percutaneous coronary intervention and 49 healthy control subjects. Plasma levels of Hcy, MCP-1, malondialdehyde and superoxide dismutase were measured.

Results Plasma levels of Hcy and MCP-1 showed significant increases in unstable angina, acute myocardial infarction and restenosis patients compared with control subjects (P < 0.05, respectively). Plasma levels of malondialdehyde were significantly increased in unstable angina and acute myocardial infarction patients when compared with control subjects (P < 0.05, respectively). Plasma superoxide dismutase levels were significantly reduced in acute myocardial infarction patients when compared with control group (P < 0.01).

Conclusion Hcy might act as an atherogenic factor through promoting chemokine, reactive oxigen species and oxidized low density lipoprotein production and thereby convert a stable plaque into an unstable potentially occlusive lesion.

语种: 英语
WOS记录号: WOS:000225673700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59505
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Inst Vasc Med, Dept Cardiol, Beijing 100871, Peoples R China
2.Peking Univ, Dept Physiol, Basic Med Coll, Beijing 100083, Peoples R China

Recommended Citation:
Wang, G,Mao, JM,Wang, X,et al. Effect of homocysteine on plaque formation and oxidative stress in patients with acute coronary syndromes[J]. CHINESE MEDICAL JOURNAL,2004,117(11):1650-1654.
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