IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Prognostic significance of AEG-1 expression in colorectal carcinoma
Song, Hongtao1; Li, Cong1; Li, Rui3; Geng, Jingshu1,2
关键词Astrocyte elevated gene-1 (AEG-1) Colorectal carcinoma Immunohistochemistry Progression Prognosis
刊名INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
2010-10-01
DOI10.1007/s00384-010-1009-3
25期:10页:1201-1209
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
资助者Natural Science Foundation of Heilongjiang Province ; Innovation Fund for Excellent Graduates of Harbin Medical University ; Natural Science Foundation of Heilongjiang Province ; Innovation Fund for Excellent Graduates of Harbin Medical University
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]ASTROCYTE-ELEVATED GENE-1 ; KAPPA-B ; COLON-CANCER ; BREAST-CANCER ; TUMOR PROGRESSION ; METASTASIS ; ACTIVATION ; IDENTIFICATION ; TUMORIGENESIS ; APOPTOSIS
英文摘要

Astrocyte elevated gene-1 (AEG-1), as an HIV-1 or TNF-alpha-inducible transcript, is associated with various aspects of tumor malignancy. However, relatively little knowledge is available related to the role of AEG-1 in colorectal carcinoma.

By immunohistochemical and western blot analysis, we investigated AEG-1 expression in normal mucosa, adenomas, and carcinomas of colorectum. By statistical analysis, we determined its relationship with clinicopathological parameters and overall survival in colorectal carcinoma.

We found that AEG-1 expression levels were gradually elevated in normal tissues, low-grade adenoma, high-grade adenoma, and colorectal carcinoma, respectively. Though AEG-1 staining mainly emerged in the cytoplasm, we observed that nuclear staining of AEG-1 tends to become more common in lesions from patients with more advanced disease stages. Furthermore, there was a similar trend for Ki67 expression (as a proliferative index) from normal mucous to adenoma and carcinoma. Statistical analysis revealed that AEG-1 expression was markedly correlated with the UICC stage (P < 0.001), T classification (P = 0.002), N classification (P = 0.015), M classification (P = 0.010), Ki67 expression (P = 0.012), and histological differentiation (P = 0.037) in the colorectal cancer patients. Besides, those patients with high AEG-1 levels had shorter survival time (P < 0.001).

High AEG-1 expression correlates with poor overall survival in the colorectal carcinoma patients. In addition, AEG-1 expression in colorectal carcinoma may be associated with tumor progression, indicating that AEG-1 may be a potential preventive and chemotherapeutic target in the patients.

语种英语
所属项目编号D2009-21 ; HCXB2010018
资助者Natural Science Foundation of Heilongjiang Province ; Innovation Fund for Excellent Graduates of Harbin Medical University ; Natural Science Foundation of Heilongjiang Province ; Innovation Fund for Excellent Graduates of Harbin Medical University
WOS记录号WOS:000281317300007
Citation statistics
Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59508
Collection北京大学第二临床医学院
作者单位1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Pathol, Harbin 150040, Peoples R China
2.Harbin Med Univ, Dept Med Genet, Harbin 150086, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Song, Hongtao,Li, Cong,Li, Rui,et al. Prognostic significance of AEG-1 expression in colorectal carcinoma[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2010,25(10):1201-1209.
APA Song, Hongtao,Li, Cong,Li, Rui,&Geng, Jingshu.(2010).Prognostic significance of AEG-1 expression in colorectal carcinoma.INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,25(10),1201-1209.
MLA Song, Hongtao,et al."Prognostic significance of AEG-1 expression in colorectal carcinoma".INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 25.10(2010):1201-1209.
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