|Prognostic significance of AEG-1 expression in colorectal carcinoma|
|Song, Hongtao1; Li, Cong1; Li, Rui3; Geng, Jingshu1,2|
|关键词||Astrocyte elevated gene-1 (AEG-1) Colorectal carcinoma Immunohistochemistry Progression Prognosis|
|刊名||INTERNATIONAL JOURNAL OF COLORECTAL DISEASE|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology ; Surgery|
|研究领域[WOS]||Gastroenterology & Hepatology ; Surgery|
|关键词[WOS]||ASTROCYTE-ELEVATED GENE-1 ; KAPPA-B ; COLON-CANCER ; BREAST-CANCER ; TUMOR PROGRESSION ; METASTASIS ; ACTIVATION ; IDENTIFICATION ; TUMORIGENESIS ; APOPTOSIS|
Astrocyte elevated gene-1 (AEG-1), as an HIV-1 or TNF-alpha-inducible transcript, is associated with various aspects of tumor malignancy. However, relatively little knowledge is available related to the role of AEG-1 in colorectal carcinoma.
By immunohistochemical and western blot analysis, we investigated AEG-1 expression in normal mucosa, adenomas, and carcinomas of colorectum. By statistical analysis, we determined its relationship with clinicopathological parameters and overall survival in colorectal carcinoma.
We found that AEG-1 expression levels were gradually elevated in normal tissues, low-grade adenoma, high-grade adenoma, and colorectal carcinoma, respectively. Though AEG-1 staining mainly emerged in the cytoplasm, we observed that nuclear staining of AEG-1 tends to become more common in lesions from patients with more advanced disease stages. Furthermore, there was a similar trend for Ki67 expression (as a proliferative index) from normal mucous to adenoma and carcinoma. Statistical analysis revealed that AEG-1 expression was markedly correlated with the UICC stage (P < 0.001), T classification (P = 0.002), N classification (P = 0.015), M classification (P = 0.010), Ki67 expression (P = 0.012), and histological differentiation (P = 0.037) in the colorectal cancer patients. Besides, those patients with high AEG-1 levels had shorter survival time (P < 0.001).
High AEG-1 expression correlates with poor overall survival in the colorectal carcinoma patients. In addition, AEG-1 expression in colorectal carcinoma may be associated with tumor progression, indicating that AEG-1 may be a potential preventive and chemotherapeutic target in the patients.
|项目编号||D2009-21 ; HCXB2010018|
|资助机构||Natural Science Foundation of Heilongjiang Province ; Innovation Fund for Excellent Graduates of Harbin Medical University|
|作者单位||1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Pathol, Harbin 150040, Peoples R China|
2.Harbin Med Univ, Dept Med Genet, Harbin 150086, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China
|Song, Hongtao,Li, Cong,Li, Rui,et al. Prognostic significance of AEG-1 expression in colorectal carcinoma[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2010,25(10):1201-1209.|
|APA||Song, Hongtao,Li, Cong,Li, Rui,&Geng, Jingshu.(2010).Prognostic significance of AEG-1 expression in colorectal carcinoma.INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,25(10),1201-1209.|
|MLA||Song, Hongtao,et al."Prognostic significance of AEG-1 expression in colorectal carcinoma".INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 25.10(2010):1201-1209.|