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学科主题: 临床医学
题名:
Prognostic significance of AEG-1 expression in colorectal carcinoma
作者: Song, Hongtao1; Li, Cong1; Li, Rui3; Geng, Jingshu1,2
关键词: Astrocyte elevated gene-1 (AEG-1) ; Colorectal carcinoma ; Immunohistochemistry ; Progression ; Prognosis
刊名: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
发表日期: 2010-10-01
DOI: 10.1007/s00384-010-1009-3
卷: 25, 期:10, 页:1201-1209
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: ASTROCYTE-ELEVATED GENE-1 ; KAPPA-B ; COLON-CANCER ; BREAST-CANCER ; TUMOR PROGRESSION ; METASTASIS ; ACTIVATION ; IDENTIFICATION ; TUMORIGENESIS ; APOPTOSIS
英文摘要:

Astrocyte elevated gene-1 (AEG-1), as an HIV-1 or TNF-alpha-inducible transcript, is associated with various aspects of tumor malignancy. However, relatively little knowledge is available related to the role of AEG-1 in colorectal carcinoma.

By immunohistochemical and western blot analysis, we investigated AEG-1 expression in normal mucosa, adenomas, and carcinomas of colorectum. By statistical analysis, we determined its relationship with clinicopathological parameters and overall survival in colorectal carcinoma.

We found that AEG-1 expression levels were gradually elevated in normal tissues, low-grade adenoma, high-grade adenoma, and colorectal carcinoma, respectively. Though AEG-1 staining mainly emerged in the cytoplasm, we observed that nuclear staining of AEG-1 tends to become more common in lesions from patients with more advanced disease stages. Furthermore, there was a similar trend for Ki67 expression (as a proliferative index) from normal mucous to adenoma and carcinoma. Statistical analysis revealed that AEG-1 expression was markedly correlated with the UICC stage (P < 0.001), T classification (P = 0.002), N classification (P = 0.015), M classification (P = 0.010), Ki67 expression (P = 0.012), and histological differentiation (P = 0.037) in the colorectal cancer patients. Besides, those patients with high AEG-1 levels had shorter survival time (P < 0.001).

High AEG-1 expression correlates with poor overall survival in the colorectal carcinoma patients. In addition, AEG-1 expression in colorectal carcinoma may be associated with tumor progression, indicating that AEG-1 may be a potential preventive and chemotherapeutic target in the patients.

语种: 英语
所属项目编号: D2009-21 ; HCXB2010018
项目资助者: Natural Science Foundation of Heilongjiang Province ; Innovation Fund for Excellent Graduates of Harbin Medical University
WOS记录号: WOS:000281317300007
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59508
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Pathol, Harbin 150040, Peoples R China
2.Harbin Med Univ, Dept Med Genet, Harbin 150086, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Surg, Beijing 100044, Peoples R China

Recommended Citation:
Song, Hongtao,Li, Cong,Li, Rui,et al. Prognostic significance of AEG-1 expression in colorectal carcinoma[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2010,25(10):1201-1209.
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